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If someone asks for a healing potion, adding other effects either does nothing or can even make them refuse to buy it if "the effects are incompatible." Frost is incompatible with healing.
However, if someone asks for a more generic potion where multiple things could work, like something that "makes me stronger in combat" or the like, then you can make a potion that has both strength and swiftness, for instance, and they'll pay for both effects.
a health potion effect SPECIFICALLY? not really. if you're on suffering or grandmaster mode you might cram in wild growth to still snag the poularity and reputation from serving them, but otherwise you'll make so little money from a custom health potion effect that it's not worth the hassle. THe base price is just too low, may as well sell more bulk brewed strength 2 stoneskin 3 potions to traders at those prices.
Also "positive" effects cannot be combined with "negative" effects; cold, fire, poison, lightning, shrinking are negative effects, so don't mix them with healing.
HOWEVER.
HOWEVER.
Some effects have a MUCH higher base price. I imagine that if some crazy necromancer wanted a necromancy potion with additional effects, it would be well worth your while to start from your void pain potion and make your way to necromancy from there, because the base price of necromancy is so high and multiple effects is a multiplier. Same idea for luck potions, the base price is pretty good, so it's worth grabbing at least one compatible effect. late/end game it may even be worth having a standard but expensive starter made from gobs of salt and stickreed or crystals so you can deal with single ingredient requests like that for even more money.
What's even juicier is when the request type can be satisfied BY multiple effects AND the customer specifically reqeusts multiple effects, as you will double dip in terms of what the customer is paying in base price from adding up the effects they want AND the multiplier from having lots of effect types.
"Protection in battle" is a pretty solid one to do this with. even in suffering mode you can hit 1-2k prices on these with your alchemy proteciton recipe (or slightly min max by giving them a variant with antimagic and one of the other effects tossed out), so in normal you'd get like 4-10k for them.