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Lady Dimitrescu has no weakness regarding the weather or the sun - she has just a blood disorder, which mutated when she got the "parasite" implanted.
"This experiment mutated Alcina's body considerably, granting her regenerative capabilities, retractable claw-like nails, and the ability to transform into a dragon-like monster and back again. Moreover, the parasite halted her aging process, maintaining her appearance perpetually. In spite of these impressive biological changes, the resulting mutation, in conjunction with Alcina's blood disease, caused her to develop porphyria. As a result, Dimitrescu needed a ready supply of fresh human blood to maintain her health, and was therefore judged by Miranda to be a failure."
-https://residentevil.fandom.com/wiki/Alcina_Dimitrescu
Here are the notes relevant to the "vampire" sisters:
https://residentevil.fandom.com/wiki/Insect_Observations_Journal
https://residentevil.fandom.com/wiki/Further_Observations