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Stims are overabundant for a reason. It's all you need to be nearly unkillable.
Aye :-)
Melee would be stronger than some range vampire weapon?
nerd rage and emergency protocols enable bloodied to be used as tank as long as no poison effects.
DR is bypassed in decryption for instance.
Melee weapons are kind of hard if the enemy is out of reach or in a group trying to quick tag everything, so range weapons would be less painful. What range weapon would be the best?
Add blocker in str to reduce melee damage, Ignifuge in end, dodgy in agility, ricochet in luck.
Add if you really want the legendary for fire/poison resist. (fire might be useless because of the end perk, poison is nice for those stupid op with poison aoe but you can just spam stim)
Don't forget about "born survivor" in agi to auto stim if you're asleep and can't hit your stim shortcut yourself. (doesn't matter if you're bloody or not, as long as your health doesn't move it doesn't use a stim, yes you can have 5% hp and it will not use a stim unless you take health dmg or rads)
That should cover the survival part. Play full health or low health it doesn't matter, you can shoot a broadsider, auto launcher, 2 shot mirv fatman at your feet if you want (just never use a vats crit in melee range with that since crits ignore resistances)
Union power armour full set + chest for emergency protocals
Overeaters x5 + cold resist x5 + sentinel/cavalier (3/2)
Large course of food to eat for various buffs
Dodgy + fireproof + sizzling style + blocker + richochet + energy absorption + PA revive
empath serums + ally using empath for the 32% reduction
= utter pve immortality
now to be fair my 5% health bloodied secret service unyielding build can tank 3 pylons and the imposter sheepsquatch just fine so its a low bar for PvE and being immortal
PvP
Union PA + Jetpack (avoiding things = best)
Assassins x5 + cold resist x5 + sentinel / cavalier 3/2
Tons of foods, tons of drugs, serums to use to negate the downsides
Full defensive perks
Infinite supply of stealthboys
= utter PvP immortality
without the stealthboys a ts e dragon can one shot you
Carry repair kits to use it. Mine doesn't take long to break.