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First is Earle (boss in A Colossal Problem). He can be very difficult to defeat. Solo can be much tougher unless you are very specifically kitted out. He’s a boss. He is also a bullet sponge. At least you get event rewards if you are able to defeat him.
Second are the ones you might find out in the wild. They have a chance of random spawning in a nuke zone at a location that has random mob spawns. Easiest place to find them is in the Sundew Grove nuke zone after a queen fight. They are almost as tough as Earle, just as big bullet sponges, and the rewards for killing them aren’t worth the fight.
If you are not in a group of players when you find one out in the wild, or have no way of getting lots of assistance. Don’t bother. You’ll just end up with no ammo, no chems, and lots of broken weapons and armor.
He didn't stand a chance against the auto-axe and at that time it didn't have pounders fourth star.
I took a piccie the second time when i came across him brawling with a Mirelurk Queen near the edge of the nuke zone where I was able to lure him out and change into armour.
It was fun.
edit:
The very first time I came across him I was also in a Hazmat suit but level 50 so ran away as I'd only just started playing the game.
https://steamcommunity.com/sharedfiles/filedetails/?id=3385645221
I was unfortunate to encounter one such exploiter near Watoga station. They had summoned 3...
Just because you are in a private world the game doesn’t scale difficulty.
To solo a colossus you REALLY need the syringers with the endangerol barrel modification to reduce its resistance by 25% this is huge changer as this will allow you to do more damage overall.. however it only lasts 1 min so you will have change back and forth with it.
Shooting the sacks on the heads will reduce its roar range and the heads take 200% more damage which stacks up too 1k per tick if you apply the syringers debuff with a quad+rapid Rail Road Rifle you can literally melt it within a few mins.
you need items that boost your crit rate and damage... damage to ghouls can work too considering thats what earl is so magazines that do that will help too wouldn't bother with it on a weapon mod because the overall damage will be no better with replacing quad ammo. So for example you need a drug that boosts damage ,magazine that boosts damage and a bobble head that boosts damage followed by using the syringers. There are food and drinks that boost stat values for this you want luck or perception.
If you have the right items and things you can boost your damage up too 1k per shot.
This can be done with any boss creature.