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For tankyness it'll be Solar Armour, Battle Genes perk (in combat healing) and the legendary perk that reduces feralness and HP per kill. It's all about maximising passive HP gain.
Plenty of ghoul perks will work without glow such as reload speed, VATS skills, weak points etc.
I'll mostly use 'cowboy' (no, not because of the tv show...) single load weapons, lever action, pump shotgun or single action revolver. The ghoul reload perk really helps here.
It's a 'ghoul lite' build and about all I care to do with the system. All my other characters will stay human as they work fine or get good utility from ghoul allergic perks or legendary effects.
ghouls only can get mutations from serums
serums suppress the negative effects for an hour
A close ranged, gamma gun, onslaught, pistol ghoul build. Not only will you do nice damage, but the radiation aoe will also keep your glow up or maxed. I haven't worked out any of the other stuff yet, though. I'm thinking like.. a Furious, Faster fire rate, faster reload, Encircler's Gamma gun.
I dunno. Theorycrafting is fun.
Serums Mutations shouldnt be able to work on them.
Ghoul will be an OP Class.
This is a poor design choice IMHO
I tried that on the PTS, didn't work. The amount you use for glow abilities outweighs the amount you get back.
Particularly if you try to max it by using the 2 glow abilities (one regular one energy weapons).
But... PTS is always high lag for me so it might actually work better on live.