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They don't protect you from acid and poison which is the cloud released by mutated enemies and other attacks
Skin is super porous.
new in box says hi
But they still block rads :-P
Some molecules are so small that they can't be filtered at all.
Some chemicals are readily absorbed by the skin. (E.g. you can sense a garlic-like taste in your mouth if dimethyl sulfoxide is absorbed through the skin and metabolised.)
The game is not realistic in any sense.
Flys away.