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Some are more viable than others. But you can most likely have fun with any build. You do not have to min/max yourself to oblivion.
Then there are the legendary builds, bloodied is best, then anti armor, then the other lesser dmg increase builds. Juggernaught is one of worst dmg increase builds.
Because the sad truth is that if a group of gulpers come at me, an auto-axe with just the 3 incisor perk slots is stronger than my 18 slot gunslinger build.
(edit: there is a 26 card slot gunslinger build that slaps, but good luck getting a quad/ffr enclave plasma pistol)
There's another +100% (+130%?) damage bonus any character can easily pick up: +60% damage bonus from weapon specific perk cards, +15% from bloody mess (luck perk), and perhaps 25% damage bonus from the psycho drug. So, low health builds start with considerably more damage. If you're also using an energy based weapon, you can add another +30% from the science perk cards.
So, expect a low health meta build to do far, far more damage than non-damage-optimized builds. Additionally, with consumables fueling VATS criticals, and very high special bonuses from low health with an unyielding set of armor, meta low health builds can live in VATS and get additional damage every other shot through the critical system.
You can play and enjoy the game with pretty much any armor/weapon choice, and you can contribute even in Kaiju style boss fights by supporting your teammates in any of a very large number of ways be it debuffing bosses with suppressor, tormentor, follow through, take one for the team, using 'team medic' or 'friendly fire' to keep your team alive, 'Injector' and other charisma perks to apply buffs to players who you revive during fights, or you can take limb crippling perks and crowd control additional monster spawns, etc.
Just understand that while you can play anything, only a very specialized build is going to have the damage to solo-carry the few fights in the game that were designed to be group boss encounters (only 3-4 come to mind) in the allotted 30 minutes for those specific fights. They have so much health and damage resistance that you can literally run from one end of the map to the other in less time than it would take a non-optimizied build to handle them solo.
https://steamcommunity.com/sharedfiles/filedetails/?id=2944394713
More Fun
https://steamcommunity.com/sharedfiles/filedetails/?id=2889813383
Pistols would be way more fun if their perk cards were not in AGI, should be in PER.
The gauss rifle is pretty decent for high damage single shot if you only have spare perception points in your build, It's just got a terrible reload, magazine size and rate of fire. these days I just do high str, big guns, I like the explosive minigun from the eviction notice event. but I don't do bloodied. there are too many random one shots and I don't like playing it that close to the belt where you pull aggro and just instantly get downed.
If you want to play around with low health but are afraid of the one shots, try a non-unyielding build that uses power armor. The 'emergency protocols' torso misc mod for power armor provides 50% damage reduction, on top of the ~42% you're already seeing from the power armor itself, on top of the actual physical energy resists. Armor piercing mutated enemies and very large hits can still be trouble but emergency protocoled power armor makes low health pretty comfortable. You just won't have that bonus 15 SPCIAL from unyielding to boost your VATS game.
When its comes to pvp however the damage is capped . The first hit will do reduced damage, This means multiple shot weapon is the deal here.