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Mirv frags work well with an auto-vamps weapon. Or if you wanna use those in combo with a vamps power fist you'll stay alive - provided you have appropriate armor to not off yourself instantly with the MIrvs. Power fist is a fine if you have explosive palm; I think there's an electric mod for it, or maybe that's the gauntlet? That might benefit from science perks as well. The combo should be decent - make sure it's faster swing speed.
If you really want to up your game OP go Pulse with Vamps Gauss weaponry.
I use plasma grenades all the time. Never had to make them as the game just gives me them from events or loot all the time so i make use of them. Nothing wrong with them they work just fine.
These are just my general use grenades i can spam. I save my nukas for more important things.
OP are you set up for Heavy weapons, rifles, melee, and explosive simultaneously?
And science?
Yes, I also use every type of grenade too, except of Molotov cocktails. When the game gives me for free, I use it. But it's not a viable way to be a real grenadier, you have to make grenades, like hundreds of them. I have dedicated Grenadier build and I make like 200 Dynamite and 100 Nuka Grenades at once. Nuka Grenades are tricky though because it's not easy to get so many Nuka Colas. And one of the best weapons for Grenadier is M79 Grenade Launcher, almost nobody uses it but I found it to be excellent weapon because it's much less ammo hungry than Nuka Cola launcher. If you manage to get 2 shot M79 its probably the best explosive weapon in the game to use it non stop. And don't forget Fire in the Hole 3 perks, it's awesome. You can drop a grenade from Wayward to almost Vault 76.
There is the talons mutation which makes unarmed melee weapons like powerfist, and mole miner/deathclaw gauntlets better without needing perks. I like using these weapons for this reason as i can get away with not needing as many melee perks to make them ok.
Just depends what you want out of this really. Jack of all trades builds using too many different weapon types tend too be poor unless you are bloodied with low hp and have adrenal reaction to make all weapons regardless of type or prefix do more damage.
Did not miss it, i got distracted on something else :)
Missile launcher is an explosive launcher so uses demo expert not the heavy gunner perks.
I would only recommend the science perks for the extra damage for laser rifles etc if you have the free space in intelligence. The extra damage they offer is tiny and is totally not worth the perk investment.