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(Sorry couldn't resist lmao.)
I recall reading crits ignore armor so idk how AA would work vs other options, if anything it would help with normal shots
I don't really like quad personally since I feel you'll run out of AP before you expand your ammo and a reload is generally long enough to allow for AP to regen but if you like having tons of ammo loaded it's perfectly fine
With uny armor. So I'm spamming the crits.
That said, plasma caster is powerful enough that with proper low health build you can make most prefixes work just fine. My main toon's plasma caster is Mutant's +50% vats crit, with just 4 mutations the Pip-Boy damage is 175+175 which is high enough for me and haven't bothered rolling a better one since I don't use them that often.
As Eriskumma mentioned anything works well with it. For your enjoyment you might want to roll several of them for varied situations if you like it - and also try some of the less popular prefixes.
God tier options are:
Anti armor with 50% vats accuracy
Anti armor with crit damage bonus
Anti armor with FFR
Bloodied with 50% vats accuracy
Bloodied with crit damage bonus
Bloodied with FFR
Executor with 50% vats accuracy
Executor with crit damage bonus
Executor with FFR
Aristocrat with 50% vats accuracy
Aristocrat with crit damage bonus
Aristocrat with FFR
Junkie with 50% vats accuracy
Junkie with crit damage bonus
Junkie with FFR
Quad with FFR
Good tier options are
Mutated with 50% vats accuracy
Mutated with crit damage bonus
Mutated with FFR
Gourmet with 50% vats accuracy
Gourmet with crit damage bonus
Gourmet with FFR
Giant with 50% vats accuracy
Giant with crit damage bonus
Giant with FFR
Quad with 50% vats accuracy
Quad with crit damage bonus
Notice how all god tiers starts with only 2 stars? That's because third star doesn't really matter when it comes to Plasma caster. It's mostly irrelevant.
But if you care about it, best options are:
+1 Special
+15% crit bonus
-90% weight
-25% AP cost is a waste. You have more than enough of AP to use weapon without this bonus.
I would consider -90% weight as probably the best of them all in a long run.
Vampire is simply not as viable here, as it would be on any aother faster-firing weapons. Simply because the heal effect does not depend on how much damage you deal, but rather how many "hits" you make, regenerating 2% HP for each hit. And Plasma caster fires slow, with a singular shot, even if high damage, so... Vampire should be best left for something different.
The only possible alternatives of the first effect comes to mind is maaaaaaaaybe Instigating, for that +100% dmg to full hp enemies, since the plasma caster deals good damage either way. And since you run Critical Savvy... Just go for 33+ Luck, just so you could have crit shots every other shot (crit - non crit to charge back to 100% - crit - non-crit - repeat). And with Instigating + Crit, you'd one-shot pretty much almost any non-boss enemy. The "elite" units (Blue Devil, Mirelurk King/Queen, etc) might become a problem tho, as Instigating only gives bonus to 1st shot...
So... If it's not Anti-Armor, nor Instigating... Bloodied? Aristocrat? Nah, AA all the way, I think.
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Followed by 2nd star being... Perhaps increased VATS accuracy or better yet, crit damage? Not that you'd need THAT much damage for non-boss enemies, since you also run Better Criticals and - I assume - crit damage food, yes?
Maybe AP regen then? Or - considering Plasma Caster's slow fire rate - might try the fire rate boost.
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As for third star... -90% weight? Durability? Less VATS cost? Maaaaaaaybe faster reloading is "alright", but only if you roll it with other good options on first two stars and don't wanna re-roll for a chance at an even better.
Not even close crits scale off the damage so bloodied crits are dramatically higher
Quad on this gun is a script roll its terrible
You want
Damage that matches (ex bloodied)
Faster Fire Rate
Faster Reload (ideal roll) or -25% ap (if you are full health and not nearly as good)
The gun defaults to 20 rounds and even with ffr and mousing its got a lot of time between reloads
Ex.
Bloodied, Faster Fire, Faster Reload = one hit kills MOST regular enemies [things like the hermit crab, mirequeens or other larger ones nah]... one hit crits any regular enemy and most 3*
My typical bloodied plasma caster regular shot is 1200 - 1800 {depends if the enemy has a good weak point} and it crits for far far far more