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Yeah, it's an annoying thing for sure. A minor inconvenience that you have to deal with, while having so much power on your hands.
Small build tip about not dying: Serendipity R3 (LCK) + Ricochet R3 (LCK) + Born Survivor R1 (AGI) + Lifegiver R3 (END) + Fireproof R3 (END) + Nerd Rage R3 (INT). Also, a weapon with Vampire effect helps a lot, as Ricochet's reflected damage also triggers the healing effect, with you not even having to shoot anything. And naturally, Marsupial + Secret Service armor + Jetpack - to always be able to escape any situation.
And yes, Born Survivor R1 - it automatically injects you with a stimpack when needed, while avoiding the animation. So you just keep on shooting and killing aka removing the danger to your survival(via murder! \o/) without "stopping" the process to inject yourself with a stimpack. And after the change that was made months ago, it doesn't eat through your stimpacks as badly as it did. A lot of outdated info on it out there. Try it and you'll see its benefits real fast.
And if after all of these you still need an extra layer of survivability: Dodgy R3 (AGI), the AP drain isn't as crazy as people claim it is, while offering a solid reduction of damage that does manage to go through all the previous "barriers". Especially if you run full set of Unyielding armor + Company Tea (or other means of fast AP regen). You usually have more than enough AP to sustain Dodgy. But that's an extra layer, for when the previous list of things isn't enough.
People recommend Toxic Goo and it's indeed a good one, but there's a bit a caveat that nobody mentions:
Toxic Goo is considered a "Food" item. And without Thru Hiker (AGI perk) or the Food-weight reducing backpack(forgot the name), each Toxic Goo bottle will weight 0.75... That's a lot. While 3 perk points in AGI can be used more efficiently when running low-hp build, especially if you aren't high level enough to toss out several SPECIAL-based legendary cards for those extra points.
As such, there's an "inferior" alternative: Glowing Blood. Yes, it gives less rads(+15), but at least it's considered "Aid" item and thus it's weight-reduced by the Travelling Pharmacy or Chemist's Backpack. I mean, who runs ANY build without either of these two, am I right?
Sure, Glowing blood is also a bit more difficult to "farm" compared to just going to WestTek and slurping the green stuff off the floor/from the barrels. But there are multiple options for that:
1) Radiation Rumble event drops A LOT of glowing blood. I once farmed over 100, while general number is usually 50-80 per the whole event. That is, of course, if you do tag enemies in time with something AOE;
2) Nuking Whitesprings Resort. Every ghoul in the area becomes "glowing" and thus can drop glowing blood too;
3) Camp-jumping/server-hopping. I was surprised how commonly people sell these for super low caps (1-5caps) and in large quantities;
It's not ideal, but at least it's an alternative to what people already offered you. But quite honestly? If you CAN somehow spare 3 AGI points in your build - go for Thru Hiker (R3) + Toxic Goo instead. I just didn't want to repeat the same others said again and again.
I use both. +40 Rads from Toxic Goo, then minor adjustments of +15 via Glowing Blood. To not "overshoot" it too much and keep around 18-19%.
Not one to tell you how to enjoy your game.
Currently in the NO mutations phase myself for several characters.
Just a fair warning about low health builds though. It's the easy mode for this game, damage buff it gives is actually almost irrelevant compared to other benefits you get from Unyielding set like massive amounts of action points, carry capacity, crazy good stealth, faster crit bar fill and way more XP from everything you do making the scoreboard progression, leveling etc so much easier and faster. Also since you can have so good stealth you use less ammo and need to repair your gear less and so on.
I made one low health toon long ago, now all my 6 toons are low health. :P
P.s. forgot to say i also have in all my camps a radiation barrel and / or an undetonated bomb. To get rads when i need it.
I take off my SS armor to lick the rock. If you think about it, that's crackhead behavior.
Low health yields +3 to each stat (-END) for each piece of "Unyielding" armor. So 5x3 = 15 INT = more XP.