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Open them slowly and wait for the animation to stop before opening another. I have had bugs in the past where they do not count when i have opened them really fast.
if you hop servers you can lose 25% - 50% of the buff - happens fairly frequently for them to be dropped
They can time out in 30 minutes instead of an hour... seems more present if you fast travel a lot
if you use them before logging off they can continue to burn time for up to the full hour (same with food and magazines) leading to waste
IF you mass buff you can have random buffs disappear (tons of food, drugs, scouts, magazine, bobble, lunchbox etc) which can include the boxes
Try to maximize the hour long boost. Berry Mentats are handy, too.