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I run about 4 mutations myself. I lost them once by mistake... I HAD to go get them again because I hated running without them =)
Neither of the two melee mutations effect ranged damage in any way.
Only one of the two melee mutations even effects ranged weapons at all. Twisted muscles mutation will reduce gun accuracy by 50%. With max class freak it is only 12.5%. Does not reduce gun damage at all. Also it is only hip fire accuracy. VATS and ADS accuracy are not changed.
Talons mutation is the other melee mutation and it will reduce Agility by 4. This also is not affecting ranged damage.
I have both melee mutations on a commando rifle build and it does not reduce my damage at all and the 12.5% accuracy nerf is negligible to the point of not noticeable. With rank 3 of class freak I can still use VATS and ADS and hit targets far away exactly the same as before I had the mutation. I believe it only effects your hip fire accuracy anyway. For me there is no difference.
But but but but. I have all mutations but carnivore.
Am I doomed?
I think they're talking about Grounded; that decreases energy damage by a minimum of 12%.
Having all the mutations at once was something people did back in the early days of the game, where those buffs were basically all you had beyond gear and perks. Now there are more factors to account for - you have to be a bit more restrained.
Like if you always play alone, avoid the group mutations.
Yeah I get bored using same weapons and same tactics all the time so I melee often too. I took both mutations for my main character with bloodied unyielding commando build.
I don't know who goes around using only hipfire all the time, so the negative effect of gun accuracy is a moot point as I almost never use hipfire. I cannot notice a difference with VATS or ADS from when i did not have the mutation. Except for having way better melee damage and cripple effect that is.