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You can flame in front of the synths too, and they'll definitely die because they're very slow.
Fire and suppressing fire is the key to beating queens, imo.
Synths wont walk through the fire if you leave a gap, they'll happily walk around the entire boss arena just to avoid touching fire, same applies to the queen
Have some tools at hand (exchange for 2 command points if needed).
Put up turrets as soon as you enter (If you barrelkill or supress the first Synthwave (hehe) from the right (?) you have enough time to place one or more .
You also have some barrels and such you can use to help kill the Synths.
I love gunners and the smart gun.
1. You can easily kite the queen as you have a lot of space to move around. Just wait for her to start preparing for her charge and simply run to the side. If she catches any of your marines grenade her, this should give the marine enough time to stand up and not get destroyed.
2. Use the barrels. Start by blowing up the barrel to your right (next to the synths). Later just run past a barrel and then blow it up. The queen and synths will follow you and move through fire and burn.
3. Granade the facehuggers.
4. You can outrun the synths most of the time.
5, Setting up a sentry gun takes time so either do it immediately at the beginning of the fight or don't bother (I didn't).
6. If you have a gunner remember to focus fire on a single target to get +10 accuracy
Turrets, one each side for synths, rest in front for queen, tear 'em down and redeploy for synths if you need them.
If they're too close for flamer, shotgun and lots of it. Trade a tool in for more of them and hope your vengeance meter is full.
By this point you should have so much firepower it's actually harder to lose the fight than win it.
you just need to use the occasional basic grenade to stun the queen. You can just do it with basic rifles and no rpg.