Optimal usage of keepsake in each region

[plutoburn]

Just curious how people choose to use their keepsakes throughout a run?

This is usually my routine:

Shackles in first, it's most useful in the beginning.
Cosmic egg in first or second area
Coin purse in second or third especially if I need to buy death defiance and I need that extra coin
And I always use lucky tooth entering Styx, because Hades.

[GeminiEclipse]

I just use the butterfly.

[Washing Machine]

Eh, the new post credits keepsake is so stupidly good I just run it entire game now.

[Giraffeguin]

I tend to do:

1. God Keepsake or Egg if want a specific build, want Chaos, or Coin Purse
Area 1 is the easiest place to do Chaos without much drawback
2. Coin Purse if I did God before, otherwise God now to compliment build. Or new keepsake added in 1.0 to raise the levels of some boons.

Basically keepsakes in 1-2 are to setup/enhance the run since the areas are generally easier than 3+.

3. Broken Spearpoint - this is the area Im most likely to take burst damage so this helps mitigate damage taken.
4. Keep broken spearpoint for same reason as above.

I used to use Lucky Tooth at #4 early on, but have since felt 3 defiances from the mirror is good enough. Only run it if I am doing Stubborn Defiance (for the prophecy mostly, I don't like it as a skill.)

[Nibbie]

As the start, I usually started with coin purse, then went to a god trinket, then collar or tooth. Once I got some experience, I used either feather or butterfly depending on my weapon, and stacking it through the entire run. Nowadays I use the post-game scaling trinket. This is all assuming I'm not just levelling my trinkets or something, as I do during all my low heat runs.

[Clown Baby]

Persephone keepsake, once leveled up you get 12+ free +1's

If no persephone then Butterfly,

-Or-

1-Coin purse
2-God I want
3-Charon(if there is a +damage armor or +Health every room)
-or-God I want
4-Tooth

[Darth Bokeh]

By zone:

1 - God keepsake or egg
2 - Complementary god keepsake or keepsake I’m leveling
3 & 4 - Acorn

[MULTIPASS]

I've been meaning to level up Persephone, but my usual setup is to use god keepsakes in the first three zones for my build and then acorn for Hades.

[Lexomatico]

Persephone all the way as it's too good. Before that shackles,then whatever. You don't need any kind of build for the first 10 hades kills if you are not a complete idiot so doesn't really matter

[plutoburn]

Do you get more mileage out of acorn compare to tooth?

[Washing Machine]

Originally posted by plutoburn:

Do you get more mileage out of acorn compare to tooth?

Maxed tooth heals 100hp, Acorn negates 5 hits. Pretty much.

[Lorska]

1. Chaos Egg to find a win condition
2. Purse or god boon for win con
3. God boon to round out my build
4. 2 defiances -> skull earring, tooth otherwise