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For the most part I find the most effective strategy to be: Start with demeter keepsake to ensure you can get both of her cast boons. Not only do the the two cold effects deal great damage and cc but also count as two separate curses for the Origination Tarot.
This combined with The furies and Huntress essentially give you an extremely easy consistent 2.3x damage multiplier before any attack/special boons. This will allow you to nuke most encounters rather trivially with almost any weapon.
Other boons are up to taste, although if you're using ranged weapons, make sure to pick either Zeus' or Hestia's boon that lets you place your cast onto enemies from far away as well.
Other recommended boons include the Healing hex (make sure to equip Selene's keepsake if you get it to maximize the amount of upgrades you can assign to it.)
Artemis' Lethal Snare (for even more dps to enemies in your cast.)
Hephaestus' trusty shield (helps nullify the "enemies deal more damage on first hit in each fight fear")
Another good idea is to switch to Narciscus' keepsake on the first floors keepsake switching station before using the fountain. If the main DPS boon you picked is a common, keep picking rares and epics for the rest of area 1 so you can use it to forcibly turn it into a heroic.
I tend to switch up my arcanas based on the weapon I use.
2, 3, 5, 6, 7, 8, 9, 10, 11, 12, 13, 18 and 24 are my default build though.
Hopefully it'll get fixed soon.