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If you are maxing your curse meter constantly, then you are buying too many things with blood and then not mitigating the corruption. That's the long and the short of it.
Me personally, I buy maybe 2 nice relics with blood, early, but that's it. I don't bother mitigating the corruption, and I hit about 4 curses by the end. If you take the +20 corruption meter blessing, it gets even easier. I'd definitely start using this.
The other way to go is to invest in mitigation, like your -corruption on kill relics and weapons. You can make the champion weapons drop sometimes, and these will remove a whole curse if you consume them.
If you want to git gud, focus on the thing that is screwing you (curse, in your case, healing would be the other big one) and spend your whole run trying to cobble together a build to overcome it.
PS if you honest to goodness aren't buying anything at all, then you are getting hit too much. Go slow and be sure to not get hit, especially at the end.
For what it's worth i feel like the game should be easier overall but it's definitly manageable. Some little advice never more than one weapon altar, focus on relics early on in exchange for blood than depending on what you found focus on gold or dmg upgrade. A good rng run is not when i found the items that i want but when ennemies drops items that i can convert into stats or usefull bonuses
I really never go beyond 1-2 blood items MAX. So, I am getting hurt too much I guess.
Again, you guys talk like if you could chose anything you want in this game. THAT is the first thing i try always to get, but i NEVER had the chance to get it. EVER. I even used all my 10 divine favors and still nothing lol. Anyways, bye bye.
1. Seek out gold/challenge room mainly. If things goes well, you can get only 20 corruption unless had a curse where you get 2 corruption every second. In addition, the gold can be paid instead of blood.
2. DODGE. Dark attacks are easily identified in purple, but most cannot be blocked.
3. Remember which enemy had dark attacks. This should help you prioritize which to look out for.
4. Have a weapon and/or relic that reduces corruption.
5. When looking for cursed weapons, check their stat. Some can cause corruption.
6. Try to get cursed weapon drop from bosses. If can, offering it to the gods will remove a curse.
7. If you are going to buy anything with blood, unless you have the curse that use health for blood sacrifice, be sure that it will be worth it.
8. Try to only get about 1-2 curses before the boss. This will be crucial especially in the long run. (You will get a curse before the boss regardless of how you go through the map)
9. Enter health room only if you need it. And if so, don't heal to full, just enough.
10. There is a blessing that increase corruption cap. Equip it if you find yourself... too cursed.
11. Sometimes, the best option to negate corruption... is to get curses.
Another note, the ideal power level of your weapon as you reach the boss (and the final true boss) is 4, but you can definitely reach 6 if you manage to reach enough upgrade altars.
Gold is how you combat corruption. Corruption is also how you combat being poor. They both are the same resources that you spend on same thing: upgrading your gear (unless you take dark dmg, ofc). As such, there's an argument to take blood offering cost reduction, gold reduction, and remove corruption to manage your gear in your run.
Final curse is also kind of negligible DPS if you have 1700+ existing HP, and cursed relics are just amazingly good.
That's because... you can. If you don't waste your chances on useless stuff.
The starting altars ensure you have at least 1, if not 2 weapons that you're skilled with, and that those are good enough to finish the game. If you want to go min-max freak about it, just start the first room and go back.
Then, what is left.
Health management ? Basically, by the time you're at the last temple, your skills should have improved and you basically shouldn't get hit in more than one room out of three. Just having 1 or 2 relics options to improve your health (like 1% life on greed kill or 8% on doors) should be enough.
Corruption management ? In the 3 boss temples, you gain 20 per room, there are about 10 rooms per boss, and boss remove 100 corruptions. That's basically 3 curses at the end if you don't get hit by corruption attacks. In the very last temple, you do get 30 corruption per room, but you can fight mini-bosses which remove corruption. It's very easy to get 6 bosses, that's basically... 3 curses at the end of the game.
Moar damage ? As stated above, you shouldn't get hit this much. This game isn't a DPS race, even if there are a few boss that are dps checks, the level needed is rather low. YOu choose your weapon at the start. All that's left is DPS. A level 4 weapon with the right relics should be enough to finish the game. That's 3 upgrades on the whole game (there are 1 or 2 upgrade rooms on each section, so that's also all that is needed). And you will get relics / stats that will boost your damage along the way.
All that means that using divine relics on relic altars (and relic altars ONLY) ensures that you WILL get all you think you need. As it will give you one or two relic that didn't drop.
What I share, however, is that the game has glaring balance issues (omg the enemies that turn backward to hit you DURING escapes, or those f******** babies with their aiming lightning... or the tendency of the lightning boss to hide inside tornadoes so he's impossible to hit...)... Or those f******* double attacks which are impossible or next to impossible to parry ???
However, you cannot say that the game doesn't give you what you need. That... simply isn't true.
I imagine that what they are doing is focusing on one specific thing they want from a given altar, and burning every chance to get it, which does have low success.
What they should be doing, and what I imagine everyone who does not feel oppressed by RNG in a roguelite is doing, is looking at what the entire build needs and grabbing whatever does the best job of filling a need when each opportunity presents itself; maybe heal on kill instead of heal on crit, maybe +crit on a spear instead of +damage, maybe grab a great healing icon, if it's available, even though you were hoping for damage, and try for damage at the next altar, etc.
Also just from "selling" items you could easily get around -200 corruption during the run (+2 bosses = at least -400 corruption per run naturally)
Learn to adapt to stuff. L2p issue.
Especially that curse attacks are usually one of the easiest to dodge (except for eagle temple stuff but it's still nothing extreme).