Best weapon/rune setup?

[TheZoomerRemover]

Whats your favorite setup in this game? So far I feel like pretty much just going heavy weapons is key, however i suck at the game so i dunno.

[Barely Cuda]

My favourite is sacrificial macana (crit when only one enemy is nearby) with shield that makes main wep crit for 2 secs after parry (stacks with initial crit of sacrificial macana so just absolutely melts bosses), and going for crit relics, plus heal for crit damage relics (I love crits ;p).

For blessings I love Reptilian Hunger with Eagle's fascination. Used to run grace of the tempest with it as well but recently got nerfed now I run the 20% extra damage reduction in light (forget the name)

[Barely Cuda]

Also if you're not aware of absolute crits:
All swords crit on finisher
all daggers crit when attacking from behind (plus finisher interrupts enemy attacks)
Pistols crit with perfect shots (plus off-hand combo interrupts enemy attacks/staggers)
spears crit by hitting with the tip (finisher staggers/interrupts attacks)
Heavy weps crit on finisher of course plus every hit staggers/interrupts (as I'm sure you're aware)
claws crit on charged attack
bows crit on perfect shot obv
maces don't crit by default but charged attack and finisher do +50% damage
shield has no crits, knockback is good for pushing into traps though

So really just depends, there's a place for every weapon (except bow really).