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Frostbite is a lot more versatile in that it will generally kill bosses during relentless rather effectively, but it lacks the multiplicative damage stacking of reap. If you're using frostbite tethys or Coldchannel Solgard, or an endless Titan Sentry, then that frostbite will add up on its own, and you really only have to worry about taking down the enemy tanks and heavies.
In the early game, its fine to use Fracture and Forgone Power together to work on making sure that waves die before they reach the Pyre, but its a temporary thing...after the first 3 battles, at most, you want to have gone one way or the other (or just gone with units with some light support from frostbite or reap). Neither one is powerful enough, in general, to work unless you go all-in on it, in which case it CAN be incredibly powerful (which generally requires investing heavily into a champion focused on that tactic, or getting the key artifacts that boost that damage type...Stygian has Cuttlebeard, and Wurmkin has the artifact that increases reap applications by 1, and the artifact that applies reap 1 randomly to an enemy unit twice when you generate an echo...along with great unit support and ideal spells.
In short....no. They really don't work that well together because they each require you to invest heavily to make them work, and you can't really invest heavily into two different things. They work fine together in the early game, but you should focus your strategy down by the time you hit ring 4, at the latest.
Reap, on the other hand, no matter how much I've tried to make work - even using Spine Chief - I just cannot. It simply doesn't stack up fast enough from my experience.
The rest of the deck did profit massively off playing Infused Cards and making everything infused, but it was by no means stacking significant other stacks of Reap.