(SPOILER) How important are omega blockers?

[Gideon]

I've read a couple guides online about the endings and from what I can tell if you take omega blockers arent important unless it is the last one on a balcony.
I'm wondering since I enjoy talking to silverhand and taking the blockers ends those conversations.
So, How important are omega blockers?

[Grobut]

If you want to see more of Silverhand, don't take 'em.

Without spoiling anything here, it's possible to play a bunch of missions involving Johnny and his past later on in the game, but his missions only become avalible if you have a good to medium disposition twords him. If you've been really hostile twords him, and for instance keep taking the blockers to shut him up, then he won't make that content avalible to you.