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Tsunami stands out the most for me even though I rarely use it. No other gun is capable of putting several thousands of damage in headshot on multiple targets, regardless of whether they are lined up or not. That's a tech sniper so the choice of perks and attributes should be obvious.
Deadeye and Obliteration provide fun feedback from shooting, so I like those. Not sure if Salt in the Wound has any.
Anyway, what is most effective depends on your entire build, not just any single weapon or weapon type. If you go all in on Body, for example, you'll definitely want to use both machine guns and shotguns, as well as your gorilla fists or some other blunt. The only trouble there is that the new and better LMG is really rare find in any configuration. But fortunately those HMG turrets are plentiful.
One thing of note you should pay attention to is armor penetration. Especially/at least on very hard, enemies pack a lot of armor. It's at least as large factor as headshot damage multiplier is.
What shottie are you using now btw? I loved headsman in old game but it looks like it's beennerfed so it's sort of not a shot gun anymore? Fires a single slug rather than 16(?) pellets?
On the other hand low damage weapons with high fire rate are terrible right now. SMGs and assault riffles do terrible damage, getting worse the higher the difficulty is and the higher your level.
As an example, my Shingen does less damage with a full mag into the head of an enemy, than my sniper does in 1 shot.
Firearms, pistols, as was already stated. I genuinely believe that pistols are op not because of perks, but because of just how many unique and very powerful pistols there are in the game (Bald Eagle, Malorian Arms, Tamayura, etc...). They are greatly balanced in terms of single shot damage, rate of fire, range, and ammo economy.
Second best in terms of firearms for me are assault rifles, actually, thanks to them being very universal, also with plenty of choices (uniques or otherwise).
Others are a joke compare to these, you can still make all weapon works on very hard though.
Headhunter used to be my favorite shotgun because it just deleted people with its insane damage, now it's become my favorite "shotgun" as basically a bolt-action rifle. Tons of fun to go for headshots with the thing.
The only downside is that it doesn't work on mechanical units or bosses.
You don't really need more damage with shotguns, just more reliability and usability, like armor reduction, chance to finish off enemies, increased reload speed, some defense from mitigation and all those goodies.
Never seen that mod, and I aim for the head and torso anyway. Carnage and double-barrels have good odds of knockdown by default and Vivisector and other mods work better with the perks. That kinda mod wouldn't be bad either of course... if it actually exists in base game and isn't part of some mod you're using?
Also, I just remembered the iconic SMG Buzzsaw has some armor penetration and increased dismember chance. It's probably the only power SMG worth using.