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What it does is that it can take longer before you do get a cold.
Then your build relies on mods. To counter this, if you were playing like say One Painful Year challenge, your build would start to break apart since you'd not be allowed any other mod. And indeed, one bite there can result in instant zombification meaning Thick Skinned isn't necessarily good there either.
Hearty Appetite and High Thirst as pretty terrible as well in my opinion. Slow Learner can be worked around but not ideal.
Burglar is a great class though.