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That being said, perks like armor piercing rounds or adaptive munitions do effect shield damage to barrier champions. Sweet Business's armor piercing rounds ordinarily can't effect champion shields, but once the mod is applied to give it that functionality it will do increased damage due to AP rounds.
As for other champions, you can ignore their mechanics if you can burst them down faster than they can be a problem. This is basically impossible once you get to higher difficulties, but on lower difficulties it's not too difficult. This also applies to all champions, barriers included. However, I personally would recommends just using the mods to interact with them since it makes them a lot easier to take down.
Yes/No?
No.
'Anti-Barrier' is a specific weapon property, and the shields that Barrier Champions create can only be breached by a weapon that specifically has that 'Anti-Barrier' capability, which will include the keyword 'Pierce' and 'Strong against Barrier Champions'.
No other weapon perk can breach a Barrier Champion's shield. Not even things that describe themselves as being effective against 'shields', like Armor-Piercing Rounds. These refer only to 'normal' Solar, Void or Arc shields that many enemies have. Sweet Business can NOT break a Barrier Champion's shield on its own.
If you want an AR to be able to pierce through a Barrier Champion's shield, it must either specifically have an inbuilt Anti-Barrier effect (no AR currently does, but compare weapons like Arbalest and Wish-Ender, that do). Or you have to use an AR Anti-Barrier mod to grant it that ability.