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But if say you're running a Hunter with the Lucky Pants exotic, I suggest you have a hand cannon in whichever slot you aren't running a hand cannon in since those pants have perks specifically for hand cannons (fast weapon swap and slow auto loading).
Same deal with Peacekeepers Titans (fast SMG switching and auto loading holster. not sure if it's slow auto loading like lucky pants or fast like the weapon perk though), have an SMG in the slot of whatever isn't already an SMG since it has perks specific to SMGs.
edit: no need to run SMG or Hand Cannon in both slots unless you want to. but for the most part, use whatever weapon feels most comfortable to your play style. like hand cannons, but don't like them to fire too fast? run a slower rate with higher impact.
in terms of average hand cannon impact to fire rate it's aggressive (120 rpm, 92 impact as baseline) > Adaptive (140 rpm, 84 impact as baseline) > precision (180 rpm, 78 impact as baseline)
edit 2:
also keep in mind weapon synergies. examples being Sturm and Drang. an exotic and Legendary combo that have perks that state the name of the other and kills with one reloads the other, and Drang kills overfill Strum to deal more damage until you reach normal magazine capacity. or less importantly is Mida Minitool and Multitool (equipping both buffs your movement speed further than normal agile frame weapons)