Game starts to look worse the longer it's open.

[Mr.Bubbles]

Doom 3. Start the game, looks alright, by the time I get past the second cutscene (Guys arguing in the office) The game gets a little blurry. After meeting with sgt. kelly, the game then looks like all edges are getting EXTREMELY jaggy. Continues from there, gets so blurry I can barely see. Set AA and Motion blur to off, everything off. Everything on also has no effect. forcing through AMD CCC different options many different setups.. No change. Longer it's open, the worse it looks.

[Vindicator]

Could you link a couple screenshots

[Elvis II]

Maybe it's trying to transform into the original DOOM.

[Mr.Bubbles]

I'll get some screenshots up.

[MrMuffinz]

It's a vsync problem I believe.

I had this when I first got the game.
Experiment with the different vsync options and try an FPS limit of 120.

If not, try finding the OpenGL dll someone posted in one of those AMD threads.
I think that was the main culprit, because they used a weird OpenGL dll.

One of those fixes it though, because I remember after I fixed it I sailed right through with as smooth as butter 60fps and motion blur.