As a single player game I like to enjoy this game with a controller. My only complaint with SkyUI in that regard is that I have to unplug my controller every time I enchant something in order to name it (but I think that has to do with remapping some buttons in game), but more importantly the "hassle" of equipping different groups/sets. I mean, it definitely works better than the vanilla setup, but it doesn't have the flexibility of using a KB with the F1-8 keys.

If it is at all possible I would love this kind of setup:
Tap ^ v < > for groups 1-4
Double tap those for 5-8
Hold < for specific item/spell keyed to [1]
Hold > for specific item/spell keyed to [2]
(Taps are <.5s and holds are >.5s)

Perhaps make the settings adjustable. Like setting which d-pad direction is which slot number, the specific timing for taps/double taps.