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Using the class skill:

The base class skill provides 50% damage resistance, 25% cold/fire/acid/poison resist, pain immunity, 10% accuracy boost, 10% move speed, 50% splash damage resist and x5 melee damage. Early on it can take our reavers if you leave yourself a melee weapon in one of the slots, later on unboosted by skilled it's probably best used to reduce damage while your reposition or to reduce the affects of an element.

Taking skilled will increase the resistances, movement speed, and damage multiplier. Skilled 3 will let you run headfirst into most things, and come out the other side straight through them.

Watch out for bleed though, berserk doesn't do anything to stop you bleeding.