All mods compressed by me and others can still cause the issue involving occasional low FPS and audio cuts, albeit at a reduced likelihood. The reason why the issue happens in the first place is as follows:

Originally posted by RF:

Game is running out of allocated memory of 256mb for models and sounds and is unable to free enough memory because your custom models and sounds are too big in file size. One way to fix it to reduce the amount of high poly models you use or simply increase the limit with this launch parameter.

-heapsize 750000 (Rounds to 512mb, which should be enough.)

You can use "mem_dump" command to see the limits.

TL;DR, having a higher heapsize value in the game's launch options increases the game's allocated memory, thus reduces the chance of getting the low FPS and no audio bugs even further (and sometimes crashes as well). However, compressed mods are still needed for a safe bet.