Prey - Achievement Guides

A complete guide on how to unlock all 48 achievements in Prey.
Use Ctrl+F and type the name of the achievement you are looking for in this guide.

Story Achievements

THIS SECTION INCLUDES SPOILERS, AS IT DOES GO THROUGH SOME MAJOR PARTS OF THE GAME. SOME PARTS ARE BLOCKED OUT TO AVOID SPOILING TOO MUCH BUT SOME MINOR SPOILERS ARE STILL PRESENT!

Facsimile

You can't miss this achievement, you unlock it by meeting January after a cutscene.

Open Says She

Another unmissable achievement.

Adrift

Around half way through the game, you'll be tasked with having to enter the cargo bay. Whilst you're about to enter the cargo bay, Dr. Igwe will give out a distress call and will require help. Simply save him in time and you'll get the achievement when completed.

A Friend in Need

You'll meet Mikhaila half way through the Power Plant, you'll find her injured and in need of a medkit, simply give her one and she'll heal herself and the achievement will pop up.

The Gates of Hell

An achievement which really can depend on the AI a bit too much, it requires you to make sure no one dies whilst clearing out the cargo bay area (The mission where you get turrets), I'd recommend going for 4 or 5 turrets instead of 3 as the turrets can be useless at times against Phantoms.

Brain Trust

Definitely go for this in the same playthrough as your "Adrift", "A Friend in Need", "Do No Harm" and "I and Thou" achievement playthrough. Simply save both Mikhalia and Dr. Igwe, make sure you haven't killed January for some ♥♥♥♥♥♥♥♥ reason, and about 30 minutes after saving the last person they should all meet up and you'll get the achievement.

Do No Harm

This achievement is easy or not depending on your style of play, if you play slowly then this will be a cakewalk, but if you play more aggressively it might be a bit difficult but not too much. The achievement is made easy as you are given a stun gun which knocks out every human enemy with one shot. Also remember to save anyone just in case as it is very possible this will impact the achievement.

I and Thou

I'd recommend doing this achievement in the same playthrough as "Do No Harm" as to get this achievement you need to complete the game in the most "empathetic way possible". Best way to do this is to complete all side missions with the best outcome. Also remember NOT to kill any human!
I'm not too sure if the choice you make at the end has any impact on this achievement, but just in case I Sided with Alex to save Talos 1 and got the achievement, though it is most likely possible you can complete the game siding with January

I and It

For this achievement I'd say do a 2nd playthrough (Or 1st if you want to do "I and Thou" 2nd) as it requires you to kill EVERYONE on Talos 1, and it must be done by you, so Blowing up Talos 1 at the end will NOT count to this achievement. The real kicker for this achievement is the fact some people are a real ass to reach, for instance there is an IT Closet Room with supposedly (I have yet to unlock it) 2 people alive inside of it, the issue is getting to the room as it requires a keycard which apparently is earned through Dr. Igwe... somehow. Excluding this killing everyone else should be easy.

No Needles

This is an achievement that might as well be done with on a 3rd or 4th playthrough as I am pretty sure it would not be unlocked alongside "Split Affinity". It's possibly the most annoying as without any abilities you put in a bad position as this game can be punishing as times, and with the max standard health being 100, it won't be easy. I'd say doing this for your final playthrough as you'd have a better understanding of what to do.
Another possible way to unlocking this achievement is just to speedrun the game. There are loads of places that you can skip with the power of glitches in this game, so if you want this easily, then i'd say speedrun it, as it can take you just over an hour if not less to get this achievement through speedrunning.

Split Affinity

Pretty much the achievement which could say how many times you'd need to complete the game, i'd say make this an achievement you aim for last, making this possibly for your 2nd and possibly 3rd playthrough. Part from that the achievement is very self-explanatory, just don't use Neuromods for Human or Typhon powers.

Awkward Ride Home

Possibly the most annoying achievement alongside "I and It", to unlock this achievement you need to complete the game escaping by shuttle only with Dahl, it's put even more annoying as you need to kill Dahl for the "I and It" achievement. I'd say when you are given the option to kill Dahl or not, make a save one which you kill him and another which you don't to make it easier. Pretty much do the same you'd do for "I and It" killing everyone on Talos 1 and When you are giving the decision to blow up Talos 1 or side with Alex, blow up Talos 1, then quickly run to the shuttle. I'd also recommend to NOT kill Dr. Igwe as he is required to keep Dahl alive due to memory reset after doing that you can kill him.

Side Mission Achievements

Best Served Cold

Annoying for the fact the mission goes on for a few hours due to you not knowing where Luka is for a while. You start this mission by saving Will Mitchell's imposter "Luka" he'll give you a mission and after completing it will give you yet another mission, after doing that Luka will betray you and run away for a while, in the freezer you'll find about 4-6 bodies. You then need to go to the fitness suite and bang on the window 3 times for the mission to continue. After a while you'll get the location of Luka and be tasked with killing him. After killing him the achievement should pop up.
You could also kill him before Luka betrays you, which'll save you a few hours.

Gift to the World

Dr. Igwe will give you a mission to recover "Gutstaf Leitner's Connectome". Simply when you get to the safe just play the audio log Dr. Igwe gives you and the safe will unlock, recover the piece for Dr. Igwe and the mission will end and the achievement shall pop up.

Self-Incriminating

I'd really recommend doing a save for this mission as giving Mikhaila the audio log will lead her to leaving your cause, whilst deleting it will keep her. Mikhaila will give you a mission to find out what happened to her father. Simply find the audio log and send it to her and then listen to the audio log with her and then after doing so the achievement will unlock.

This Never Happened

For this achievement you need to knockout Dahl, not kill him. Dr. Igwe is also required for this mission. Dr. Igwe will recover Dahl and then reset his neuromod before he was tasked to wipe out Talos I. After this is done the achievement will pop up.

You Rang?

To earn this you need to have unlocked 3 typhon abilities for the "Nightmare" to spawn in. After killing or evading the first Nightmare, January will give you a mission to be able to lure or attract the Nightmare, simply find an antenna (I found one at the "Hardware Labs" near the exit to Talos I Exterior) and place it on the satelite on the Talos I Exterior. Simply enter Talos I and save to avoid fighting the "Nightmare" as they are a pain, then play the audio log "Summon Nightmare" and the achievement shall pop up.

Black Market

This achievement is definitely annoying as it requires some backtracking, though not much. You unlock the side mission in the Arboretum near the lift, you should find a body with an audio log, simply play the audio log and the mission will start. You can find one stash next to the body (Where the flashing orange light is), simply hit it 3 times and it'll open, do this 5 other times for the other 5 stashes.

• The first one is next to the body. Where you start the mission.
  
• The second one is in the Crew Quarters Fitness Center, to the right when you walk through the door to the area.
  
• The third one is in the Talos I Lobby Museum. Near the neuromod.
  
• The fourth one is to the left of the Talos I Lobby bathroom.
  
• The fifth one is in the Hardware Labs on the catwalk behind the giant statue.
  
• The final one is in the Cargo Bay where survivors have taken residence.

Typhon/Human Ability Achievements

I'd recommend doing all these achievements on one playthrough.

Know Thy Self

A very easy achievement, all that you need to do is find a neuromod (you'll find 1 extremely early on in the game) and use it for a Human ability.

Know Thine Enemy

Another easy achievement, all you need to do is wait till you get the Psychoscope and scan any typhon enemy, whenever you are able to unlock an ability for Typhon powers, do so for the achievement to pop up.

Operator

Another easy achievement, the difference is this one requires a bit more time put into it, you need to hack 20 hackable object, I'd recommend getting the highest Hacking ability to save time, but it can be achieved with Hack I, but would require a lot more time.

Dead Calm

This achievement requires the "Combat Focus" ability which is a Typhon ability and then you just need to kill one enemy whilst using the ability. Excluding the fact you need to unlock Typhon abilities, it's a very simple achievement to unlock.

Engineer

Just like "Operator", it's an easy achievement that requires time to earn, and just like "Operator" I'd recommend unlocking the highest Repair skill to save time, alongside this you'd need around 40-60 spare parts, you can find spare parts around Talos I or dismantle weapons (requires Dismantle skill) to earn some. Simply repair 20 objects and the achievement should pop up.

Deprogramming

I am not 100% sure, but it's very possible this is a missable achievement due to the fact I only encountered mind-controlled enemies twice in the game, and never afterwards. The earliest you can earn this achievement is by unlocking the "Mindjack" ability in Typhon powers and using the ability on the guy in the Quarantine section of the Trauma Center. So whatever you do, DO NOT kill or knockout that guy as he WILL disappear afterwards. The only other encounter with mind-controlled enemies I know of is in the Crew Quarters.

A Different Side of Yu

This achievement requires two things, the Psychoscope and Phantom Shift (would recommend Phantom Shift 2). All you need to do is use the Phantom Shift ability and quickly use the Psychoscope to scan the shadow you leave behind (Phantom Shift I leaves the shadow for 4 seconds, whilst Phantom Shift 2 leaves the shadow for 8 seconds).

It's Alive!

Simply unlock the "Phantom Genesis" ability (can be earned by scanning 2 Weavers) and use the ability on a dead human corpse and it will transform into a friendly phantom.

Thoughts Can Kill

The achievement in itself is very easy, just unlock the Psychoshock ability and when you reach the "Cargo Bay" area, just make a separate save and use the ability on a human, then reload the save, as doing so won't interfere with the "Do No Harm" achievement.

Mimesis

Personally I find this to be the funniest thing to do as it just makes no sense, but simply just unlock the "Mimic Matter" power and when you find a mimic who is an object just mimic the mimic who is mimicking an object (Mimic-ception?).

Tee One Up

This achievement is annoying more so as it requires to scan 3 poltergeists to unlock the ability. But when done so you need to unlock the "Lift Field" skill to make an enemy float in the air for a few seconds and kill the enemy whilst in the air.

Shapeshifter

Personally surprised on how rare this achievement is, all it requires is to unlock the "Mimic Matter" achievement and mimic 20 objects, when done so the achievement will pop up.

Ball Lightning

This achievement is more so difficult as it requires 2 operators being very close to each other to take them both down at once with the "Electrostatic Burst" ability. Whenever you get the chance to take two down at once, do so and when they both fall down you'll get the achievement.

Escape Velocity

An achievement which sounds easier than it is, it requires two abilities, Mimic Matter I, and Kinect Blast I. The difficult part is also finding somewhere to get the achievement, I did it in the Arboretum near Alex's escape shuttle, but this can be done in many other places, most preferably in the Talos I lobby.

Makeup Exam

A difficult achievement as it requires using 3 specific abilities at 3 specific moments. These 3 abilities are "Kinetic Blast", "Mimic Matter" and "Remote Manipulation". You need to go all the way back to the "Neuromod Divison", all the way back to the testing area and then restart the test to be able to do the test.
On the first test use the "Kinetic Blast" ability to remove all blocks from the area.
On the second test use the "Mimic Matter" ability on the chair.
And on the third area use the "Remote Manipulation" ability on the button to activate it.
After doing all three tests like this you should get the achievement.

"Collectible" Achievements

Prism Master

For this achievement you need to find and read all 6 "Starbender Cycle" books. I did find some books more than once, though apparently 2 books are found only once.

• Starbender Book 1: Hardware Labs - Climb up onto the Grav Lift shaft at the top of the Atrium. On top, move left on the tiles to find a vent hiding spot with one of the collectible books.
  
• Starbender Book 2: Hardware Labs - From the bulkhead that leads out to the Talos 1 Exterior, go left and move the Leverage 3 large, white-covered crates blocking the path. Find the book in the caged office area guarded by a Typhon drone.
  
• Starbender Book 3: Psychotronics - In a locker in the Women's Locker Room, in the Decontamination area.
  
• Starbender Book 4: Arboretum - Down from the streaming waterfall, find the nook with the JFK memorial bench. The book is on this bench.
  
• Starbender Book 5: Cargo Bay - Toward the Shipping and Receiving area, look in the small office opposite the Medbay sign on Level 2.
  
• Starbender Book 6: Crew Quarters - Found in Alex Yu's Suite in the Crew Quarters. Get the keycard from Alex Yu's office safe in the Arboretum.

TranStar Gourmand

Another painful achievement, this requires you to find and consume every single food and drink around Talos I. I'd say whenever you find food/drinks consume it unless you know for certain you already consumed it. Just in case here is the list of foods/drinks you need to consume with locations
Food:

• Methuselah Apple (Location: Talos I Lobby, on the upper floor of the lobby in the office where you must view the video file as part of a main objective)
  
• Sunburst Banana (Location: Talos I Lobby, on the upper floor of the lobby check the front desk of the office with the recycler and fabricator)
  
• Sun-Dried Tomata Jerky (Location: Hardware Labs, in the Machine Shop where you must find the Artax Propulsion System blueprint to advance in the story)
  
• Russian Blinis (Location: Psychotronics, Live Exam room. After using the console to unleash the electrified Phantom loot the corpse of that phantom. This could be a random drop and you may find Russian Blinis from other corpses).
  
• Big Bang Candy (Location: Crew Quarters, Recreation Center, on a table upstairs)
  
• Captain Spree’s Fish Sticks (Location: Crew Quarters, Kitchen)
  
• Jellied Eels (Location: Crew Quarters, Kitchen)
  
• Siskak Unagi Rollz (Location: Crew Quarters, Kitchen)
  
• Jamon Tomato (Location: Crew Quarters, Crew Cabins A –W. Mitchell’s room)
  
• Udon Noodles (Location: Crew Quarters, Crew Habitation Pods, Joshua Vanstry’s pod)
  
• Veggie Blend (Location: Cargo Bay, Cargo Staging Area on a table with lots of other snacks)
  
• Spiralite Cookies (Location: Cargo Bay, Cargo Staging Area on a table with lots of other snacks)
  
• Skyking Pomegranate: (Location: Cargo Bay, Cargo Staging Area on a table with lots of other snacks)
  
• Ossetra Caviar (Location: Cargo Bay, Cargo Staging Area on a table with lots of other snacks)
  
• RanDom Dim Sum (Location: Cargo Bay, Cargo Staging Area on a table with lots of other snacks)
  
• Shaker Lemon Pie (Location: Shuttle Bay, inside Dahl’s space shuttle. You have to access it during main mission “The Repo Man”.)
  
• Crispy Fries: (Location: during main mission “Perdition” in Alex’s bunker. After finally meeting with Alex he gives you his aiming key. Now a monster attacks and he gets unconscious. To save Alex you must drag him into his bunker where a lot of food can be found).
  
• Glucassist!
  
• Sunburst Banana Pudding
  
• Sunburst Bananas
  
• Moonshade Lemon (Location: Crew Quarters, in the Cook's Cabin)

Drinks:

• Kings & Way Sprinkling Water (Location: Your Apartment, where the game starts)
  
• Cold Mountain Green Tea (Location: Neuromod Division, in the restroom by a toilet)
  
• Duck Beer (Location: Hardware Labs, on a table in the auditorium facing the demonstration stage)
  
• PopStar
  
• Old Sardar Bourbon (Location: Crew Quarters, in the bar named “The Yellow Tulip” on the map. It’s on the 2nd floor of the crew quarters).
  
• Kafe Karsk (Location: Crew Quarters, Recreation Center on a table upstairs)
  
• Pomegranate Moonshine (Location: Crew Quarters, Kitchen)
  
• Tamizdat Vodka (Location: Crew Quarters, Crew Habitation Pods, Harley Grainger’s pod)
  
• Green Beetle Gin (Location: Shuttle Bay, inside Dahl’s space shuttle. You have to access it during main mission “The Repo Man”.)

Press Sneak

An achievement which i'm 99% sure is glitched as it requires you to read every email around Talos I, but many people (me included) have reported unlocking this achievement though not have read all emails. I'd say whenever you find a terminal, unlock it and read all the emails. Keep doing this until you unlock the achievement. I unlocked it in the Power Plant area and had read every email beforehand. (I hadn't read the emails on Talos I Bridge).

Psychometry

Yet again another achievement that is most likely glitched as it is possible to unlock without listening to all transcribes (The game's audio logs), you just need to listen to all transcribes. They can be found in a lot of places, some on/next to corpses, some layed around on desks. The issue with this achievement is transcribes are littered around the whole map and are very difficult to keep track of position wise. Best way to unlock this is to make sure you check every area for transcribes until you unlock this achievement. Yet again I unlocked this in the Power Plant, before even going to the Talos I Bridge.

Dear Future Self

For this achievement you need to listen to all transcribes left by Morgan Yu (yep, yourself), there are 6 to find with one being missable so be very careful about that.
To help I'd use this video.

Missing Persons

This achievement sounds difficult, and to be honest it is slightly, but alongside "Psychometry" and "Press Sneak" it's glitched.... I got the achievement with about 20 people left to find. There are about 3-4 people you can miss on completely, being found in the shuttle bay. But all you need to do is whenever you find a body just check it and it'll count towards the achievement (They also have loot that can count towards "Psychometry"). If you miss a body you can always check security terminals which are found in every area to see their location.

Other Achievements

Coffee Break

All you need to do for this achievement is access Dr. Calvino's secret stash in his workshop. You need to retrieve his keycard from his body from the Talos I Exterior. When done so open his workshop up and turn on the power for the station. After doing so you can use a terminal which has 2/3 looking glass videos to watch. One of them will show Dr Calvino opening up his secret stash with a bottle. That said bottle can be found under the staircase on top of a red toolbox, the bottle being called "Dr. Calvino's Tumbler", pick this up and take it to a small scale sitting on top a table on the other side of the room and place it on top it and the stash will open and the achievement shall pop up.

Reduce, Reuse, Recycle

For this achievement you require the "Recycler Charge". The best area for this achievement is the "Ballistic Labs" in the "Hardware Labs" section of the game. Simply throw the recycler charge to the right of the room (in the middle on the two desks) and you should get the achievement when the charge sets off.

Cold Dead Hands

Currently as this moment this achievement is actually really easy. You need the "Gunsmith III" ability and about 15 weapon upgrade kits. You can get a weapon upgrade kit fabrication plan in the Machine Shop in the Hardware Labs and due to the "Materials Exploit" you can get unlimited resources. If patched the achievement is still relatively easy as weapon upgrade kits are scattered all around the place

Suicide by Proxy

This achievement can be unlocked after meeting January, simply just make a save and kill him and the achievement should pop up.

Intrinsic Value

All you need for this achievement is about less than 150 health and a Recycler Charge, you can earn this achievement the same time as "Reduce, Reuse, Recycle". Simply just throw a Recycler Charge at your feet and wait for it to set off, it should kill you and the achievement should pop up.

No Show

The earliest possible achievement in the game without glitches, all you need to do is kill yourself in the beginning simulation, when you get to the helipad jump on top of the helicopter and then get yourself killed by the rotors and the achievement will pop up.

Mimic Massacre

The most annoying part about this achievement is finding five mimics all at once. I'd recommend having a Typhon Lure and Recycler Charge. The best and really only place for this is just after the room "Labs A" where you'll find a wall blocked off by glue, simply go to the left of that glue and break it, then immediately throw a lure on the other side of the glue. Enter the room and you should hopefully see 5 or more mimics next to one another, throw the recycler charge at them and they should all die at once from the charge and you should get the achievement popped up.

Push the Fat Guy

Annoying for the fact you don't meet Alex until near the end of the game, when you do meet him just kill him, I'd say do it the same way as the "Suicide by Proxy" achievement, so create a save before killing Alex.

Mooncrash DLC Achievements - Part 1 *UNFINISHED*

As of yet I am not 100% sure how to obtain these achievements, but as soon as I know I will update this section.

I'm Your Biggest Fan

Luckily for this achievement, the Starbender chapters don't randomly spawn, and stay at one place.

You can find Chapter 1 in the small room you begin the DLC at. Before starting the simulation, go to the right side of the chair when facing the screens. You'll find it on the floor.


You can find Chapter 2 on the fourth floor Administration Level of Crew Annex in the corridor outside Alex Yu's office on a table between two chairs. You go to the office next to Alex's office at the start of the Engineer's story mission.


You can find Chapter 3 in a toilet in the Locker Room/Restroom in the path running under the Crater's surface between the Command Center and Pytheas Labs. If you go tot he bottom of the Command Center, where Power Control is, you'll find the path you're looking for is to the right of the Power Control Door.

Sometimes this corridor will be blocked, so you'll need to use the Mimic ability to pass through the opening. If you don't have it, you can enter the Labs on the Crater surface by passing the Typhon Scanner, looking to the left to find a semi-hidden path. This leads to an elevator that goes down and leads you back to the Locker Room/Restroom to get this Chapter.


You can find Chapter 4 in Moonworks in Joan Winslow's office of Mid-Level.


You can find Chapter 5 at Crew Annex in Habitation Modules 41-48 on the first floor Residental Level. You'll find it at the back of the room on the right laying on a desk. You might need to search nearby corpses for a key to the room.


You can find Chapter 6 in the Pytheas Labs at Volunteer Containment. You'll need to find a nearby Security Station to unlock the cell doors (the terminal is the light blue marker near the center of the screenshot below). The one containing this chapter is Cell 5 all the way back past the Typhon Scanner. It's under the bed in the center of the chamber.

Contract Fulfilled

Three-Body Problem

You must first obtain a Gloo Charge. You can find it in one of three ways:

1. Find the schematic for it, and craft it at a crafting station.
2. Find one randomly whilst looting.
3. Buy one before starting a run after finding the schematic for it.

I'd also recommend having a typhon lure for this. It can be obtained the same way as the Gloo Charge.

Honestly, this one is a pain as you have to find 3 enemies close enough to obtain the achievement. I'd recommend looking for a telepath and his group of mind-controlled humans, they spawn randomly but you could have some luck in the Crew Annex's Fitness Center or the Pytheas Labs' Quarantine Room.

When you find them, sneak up to them undetected and throw a typhon lure close enough that the enemies will here it, but far enough away that they won't see you. Wait for the mind-controlled humans to gather around the lure, and throw your Gloo Grenade at them hoping you get all three.

If you miss or just don't get all three, you can restart (Alt+F4) as the game autosaves when you enter an area. Don't Save and Exit though, as it won't restart at the autosave then.

Apex Predator

Galaxy Brain

Quantum Leap

Psychostatic Efficiency

You must first obtain the Psychostatic Cutter, this can be done in one of four ways:

1. Find the schematic for it, and craft it at a crafting station.
2. Grab one from the first floor of the Pytheas Lab in the Psychometrics Office. There will always be one that spawns here.
3. Buy it before starting a run after finding the schematic for it.
4. Start a run with Claire Whitten, she begins with the weapon in her loadout by default.

Honestly, this one is a pain as you have to find 3 enemies close enough to obtain the achievement. I'd recommend looking for a telepath and his group of mind-controlled humans, they spawn randomly but you could have some luck in the Crew Annex's Fitness Center or the Pytheas Labs' Quarantine Room.

When you find them, sneak up to them undetected and throw a typhon lure close enough that the enemies will here it, but far enough away that they won't see you. Wait for the mind-controlled humans to gather around the lure, and shoot the cutter projectile at them hoping you get all three.

If you miss or just don't get all three, you can restart (Alt+F4) as the game autosaves when you enter an area. Don't Save and Exit though, as it won't restart at the autosave then.

Cryptomancer

You have to finish all Kasmas' objectives to finish the game. And have more than 50,000 sim points in your possession for this achievement. You don't need to get 50,000 sim points in a single run, it's cumulative. BUT after doing all the objectives and escaping with all 5 characters in 1 run, you will be forced to start a new game, losing your progression. So make sure you only finish the game after getting 50,000 sim points in your possession.

Squad Goals

You need to unlock all 5 playable characters to unlock this achievement.

Andrius Alekna
You unlock him automatically at the start of the DLC.

Riley Yu
You unlock her when you find her Psychoscope. You can find this on the top floor of the Pytheas Labs.

Joan Winslow
You unlock her when you escape the moon with Andrius Alekna.
I'd recommend using an escape pod to escape as soon as possible.

Vijay Bhatia
You have to examine his body to unlock him. This one can be a bit annoying considering his corpse changes location, so you'll need to use a Security Station to track his body.

Claire Whitten
You must complete the story objectives with Vijay Bhatia. This requires finding the Memory Block in Vijay's room (in the Crew Quarters). Then to find a Security Station and track Claire Whitten. Reach the destination and examine the file on her computer, you'll then get poisoned, which'll put you on a timer to get to the antidote and use it. After this, go to the control tower in the Crew Quarters and Deactivate the Explosives and then you've unlocked her.

Mooncrash DLC Achievements - Part 2

No One Left Behind

First, you'll obviously need all characters unlocked.

I'd recommend using Joan to finding as many fabrication plans and Neuromods as possible as she has the largest inventory so she can collect a lot of items to break down into Neuromods.

You'll need to have:

• Escaped as Riley Yu by uploading your consciousness 1 time.
  
• Find/craft/buy 1 Neuromod with Vijay to learn the Pilot ability.
  
• Find/craft/buy enough Neuromods with Claire to learn the Hacking II ability.
  
• Find/craft/buy enough Neuromods with Joan to learn the Repair III ability.
  
• Find the fabrication plans for:
  - Shotgun.
  - Shotgun Ammo.
  - Med-Kit.
  - Propulsion System.
  - T-Radtion (or Food).
  - Anti-Rad
  - Escape Pod Navigation Chip
  - Control Unit
  - EMP Grenade
  - Effect Cures (not 100% necessary).
  
• Knowing the layout of each area so you can get around with ease will also be a massive help. I'd even say escape by each method at least once beforehand so you know the routes.

Standard Set
Equip all characters to take a Shotgun, Shotgun ammo (around 50), 5 Med-Kits and 5 EMP Grenades (more if you have a lot of Typhon abilities)
When doing the run for Joan, Riley and Claire, you'll also need a Propulsion System. But not for Vijay or Andrius.

Joan
Equip her with the Standard Set and 4x Control Units, 1x Anti-Rad and 5x T-Rations. You'll have to find some Spare Parts during the simulation or break down items if you have the Dismantle abilitiy.

When you load in, head directly to the Security Station in the middle of the Crater, but DON'T pick up the extra Propulsion System off the corpse on the way. Check the Station for the location of the functioning Escape Pod (Remember this later for your run with Andrius!), for Tram Power and for other Hazard warnings.
Enter the Power Station area next to it and install the 2 Control Units in if any area is without power. (If they all have power you can drop 2 Control Panels here for extra space)
Next head to Pytheas Labs from the Crater and run to the Mimic Portal at the back of the labs. Repair the machine.
Return to the Volunteer Cells and unlock cell 5. Pass through the Typhon gate and collect at least 5 drinks from the cell.
If Moonworks Tram Station was powered when you checked at the Security Station then head upstairs to the Tram Station.
Power the Tram(if needed) and go to Moonworks.
If Moonworks Tram Station was not powered when you checked at the Security Station then head back to the Crater, and then to Moonworks.
Inside Moonworks, head to the bottom of the central mine and place the Anti-Rad, 5 T-Ration and 5 Drinks inside the marked shipping container.
Repair the Grav-Lift next to the container and ride it up to the Mass Driver.
Head to the Mass Driver console and activate it; you have only 60 seconds to make it back inside the shipping container, either by riding the Grav-Lift down or by jumping with the Propulsion System.
Escaped


Riley
Equip her with the Standard Set.

Head directly to Pytheas Labs and navigate your way to the Directors Office (If the stairs are broken, you can climb a pipe to the left of the balcony).
Log into the computer and access Channel 0.
Head upstairs and place the operator on the workstation (If the stairs are on fire, run through it).
Upload the data to the Operator and then move it to the extractor.
Sit on the chair.
Escaped


Claire
Equip her with the Standard Set.

Head directly to Pytheas Labs and navigate your way to the Mimic Portal.
Hack the Work Station.
Stabilise the portal and then open the door using the Workstation (you're timed here).
Run into the portal.
Escaped


Vijay
Equip him with the Standard Set.

Head to the Shuttle Bay on the third floor of the Crew Quarters either running past or figthing the Typhon along the way.
Enter the Shuttle and kill the Mimic in the storage room at the back of the Shuttle.
Enter the cockpit of the Shuttle and sit down.
Escaped


Andrius
Equip him with the Standard Set and a Escape Pod Navigation Chip.

From your run with Joan at the security station, you should know which area has a functioning Escape Pod.
Go to that area and make your way to the Escape Pods.
Open the Pod and place the Navigation Chip in the hole underneath the screen.
Close the Pod and activate the screen.
Escaped

Thanks to RadiationTroll for posting this solution on TrueAchievements.com.

[Kasane Teto]

along with do no harm which i guess makes sense considering the game doesnt consider mind controlled people as people?

[Kasane Teto]

i actually got thoughts can kill along with i and thou bcz i accidentally killed a mind controlled human with psychoshock

[Vritra]

all leverage obstacles are redundant with recycler charges. You can also use a normal object to force the heavy objects to move.

[KiritoKudo]

I'm doing split affinity right now, how do you get through the door to the data vaults if you don't have leverage 3? Any ideas would be great. I only have 2 neuromods and would need 8 more for leverage 3.

[Tormènt]

iirc The Storage room in the Coolant chamber has a bunch of mimics that all come out at once.

[Sir Jia Xing]

Missing Persons, Press Sneak, and Psychometry seem to be lenient where after finding a number of people, reading a number of e-mails, and listening to a number of audiologs, the achievement will proc. It doesn't have to be 100%, but something like 85% maybe is enough, at least that's how it worked for me... That, or it's because over the course of my playthroughs, i've completed everything from the said achievements.

[Joey Stick]

Thanks for the guide.
One question:
Is it possible to achieve the trypanophobia achievement, or for that matter the split affinity one, by prematurely finish the game by escaping in Alex pod during "who is December"?
I mean, does it count as finishing the game?
Thanks

[MoonSugarTravels]

Would be great if you put the hidden achievements into a separate section, so we could avoid spoilers.

[Kasiornis]

Just wanted to share that I got Psychostatic Efficiency by hitting group of Cystoids and it's much easier this way since their nests are usually found in groups of 4-5 giving you more tries. Won't work with GLOO charge achievement since they're just exploding instead of being GLOOed.

[hobbs]

@Jakethybro Thanks for the response :) I'll try it out!