how to get yourself a runepowder bomb

don't miss a free runepowder bomb in act 1!

how to make Philomeen to give you a runepowder bomb

make sure to find Philomeen before you deal with Nere, because she will leave if you come to her hiding place after the Nere quest! At least that happened to me in several playthroughs - when i came after doing Nere quest, she was gone, when i came before, she was still there.

alternatively you can steal the whole barrel!

getting all possible powder

As we know now there are 2 barrels of runepowder, big and small. This is how you can get both!