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翻訳の問題を報告
And the only skills that matter damage wise are Flesh Rot and Blood Curse. Shadow/Frost Affinity don't interact with either of them and therefore have no value to this particular setup.
The Death's Bond and Splitting Throws runes are irreplacable, and Shattered Spirits is almost like an instant-kill mechanic when it goes of. Running Ritual of Desecration makes no sense outside of boss rooms.
As for boss rooms, losing Ritual of Banes makes you take 48% more damage. If you try to mitigate that (e.g. by swapping out the Murmur rune on the helmet for Life Guard, or adjusting your mana conversion rate on Cosmic Cape to strengthen your barrier by 48%), those attempts usually lose you more damage than you could get back from the Desecration rune.
The only possible way is to run a glass cannon build, where you don't care about the loss in damage reduction and pray that you survive still. I haven't tried that yet because I wanted to make the build tanky for the purposes of the guide. Feel free to test the waters! Definitely a great alternative as long as you can stay alive.