Plague Inc: Evolved: Prion (Normal)

A guide for the subtle Prion in Plague Inc: Evolved. Compatible with Plague Inc, won't work on Brutal.

Gameplay

Let's immediately start with our continuity error.
Prions don't have DNA or RNA. They are simply misfolded proteins that have the potential to lead to neurodegenerative diseases, namely Alzheimers (cough cough, Simian Flu, cough cough) and Parkinson's Disease. They also can't be cured in real life due to them not having DNA/RNA.
Also, it's pronounced "pree-on".

The Prion is a unique plague in that it is harder to cure and any traits will take a while to enable. This leads to a slightly longer game. To unlock it, you must beat the Parasite.
https://steamcommunity.com/sharedfiles/filedetails/?id=2356049407

As for the Prion's special ability, it has Neural Atrophy, which slightly increases cure requirement and reduces research speed.

Genes

DNA Genes

As usual, Cytochrome Surge or Metabolic Hijack.

Mutation Genes

Although the cure requirement is 20% higher for the prion, use Genetic Mimic. You can't cure a prion :)

Travel Genes

Teracyte. As usual.

Environment Genes

Extremophile...

Evolution Genes

nothing :)

The Game

Before You Begin

Allow non-lethal symptoms to mutate.

Part 0.5: The Beginning

Begin in South Africa.

Part 1: Early-Game

Save up for 50 DNA.
Under Transmissions, get Air I, Air II, Water I, and Blood I.

Save up for 50 DNA again.
Under Transmissions,, get Water II. Under Abilities, get Drug Resistance I, Heat Resistance I, and Cold Resistance I.

Save up for 100 DNA.
Under Abilities, get Drug Resistance II, Heat Resistance II, Cold Resistance II, and Genetic Hardening I.

Part 2: Endgame

Save up for 45+ DNA and infect everyone.
Under Symptoms, get Coughing, Sneezing, Immune Suppression, Total Organ Failure, and any other lethal symptoms. Devolve all transmissions and abilities (except Genetic Hardening) and, as soon as possible, purchase every Genetic ReShuffle.

You win!

[will_i_am33048]

Instead of heat resist 2 do insect transmission

[will_i_am33048]

Also never get heat resistance 2, it's basically useless

[will_i_am33048]

India is probably a better place to start since it has more people

[RedFireChaosVR]

Followed the guide.
And it didn't work. Left me with Iceland to be the lone island of survivors.

[BuddhaonaBus]

Fail

[chair]

this guide did not work

[s1mple]

thank you i won at 90%

[PhantomioDmo]

dam bro ur a legend if not u i wouldnt beat any of these gamemodes thank you man

[kenzyferguson25]

To the people saying they lost with this, I do not know how lmao. I won this in under 1000 days, with a cure of less than 50%. Thank you SOOOO much for this guide!

[ChloeLoveheart]

i followed both guides and lost