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Many adventure games use the keyboard to move (for example, Doctor Who), and the same goes for point and shoot games. That's why I'm asking about specific games, rather than genres (like World of Goo and Peggel, so thanks for those!).
Holy &^%@, I think I'd jerk him off my lap if I played Geometry Dash! lol. That game is pretty brutal...never heard of it until now. Thanks. :)
http://store.steampowered.com/app/251150/
This game is an absolutely beautiful and pretty large metroidvania focused on exploration and discovery and gradually unraveling a storyline. It can be played by mouse alone (and I think it might almost be playable by left hand keyboard alone but requires mouse to aim).
http://store.steampowered.com/app/24420/
Also, this (which can also be set to play like a turn based rpg if you want).
http://store.steampowered.com/app/32370/
Turn based and everything except rotating the map(Q/E) is done with the mouse. Left click for selecting/dragging the map view around, scroll wheel for zoom and right click for clearing selections.
http://www.giantbomb.com/one-handed-gameplay/3015-1790/games/
EDIT: and this: http://www.reddit.com/r/Games/comments/19iq00/what_are_some_good_games_that_can_be_played_with/
http://store.steampowered.com/app/237930/
http://store.steampowered.com/app/264200/
http://store.steampowered.com/app/288160/
Also, consider your mouse: with the right mouse, such as a Razer Naga which has a 12 button thumb array, you could easily assign many functions to the thumb pad and play even more games one handed.
http://store.steampowered.com/app/223810/
Not sure about the second game, but I doubt it since I know it has a magic spell attack.