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This project is not the first one done in human history. Most of the history of our ancestors are either lost or kept hidden.
They already did [have hope] but they're ignoring a lot of nuances that are the difference between this & that.
Of course, I'm sure (inb4 "prove it") it's still probably possible but it's not as simple as smashing a cat & a human together & getting only the addition of the ears & tail & nothing else.
Plus, ethical issues again...
https://youtu.be/dLx3JlDe7J0
A being that might look like something out of a lovecraftian eldritch horror book.
Edit: An example could be Gorefield, aka SCP-3166.
https://www.youtube.com/watch?v=ZsgoLh-UVdw
That's what I expect to be the most "soft" hybrid or attempt of a fully developed "catgirl". Messing around with DNA might still lead to a Black Swan event.
biopunk