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It might be slower but I doubt you will see a difference that's if it works... I've never mixed and matched ram
dual channel or hybrid/mixed/flex is better than a single dimm
The amount of RAM being 48GB won't matter at all and is plenty. 32GB is ideal these days for gaming and multi-tasking.
If you have an Intel motherboard, you might had Duel channel memory, this means slots 1&3 as well as 2&4 work together (so when you place in your RAM have it 8GB | 16GB | 8GB | 16GB). It will make it slightly faster to access and work together better.
Make sure under your BIOS you set the best XMP profile on your RAM.
Frequency + Timings + Voltage.
If you have 2x 16GB then that's plenty.
If you really need more then do either 64G total (2x 32GB) or 96GB total (2x 48GB) if Motherboard supports that.
Many modern Motherboards have an updated BIOS you can apply; allowing support for the RAM that are available in 48GB; but do not do 1x 48GB; stick to using the Dual Channel methods.
For Gaming, 32GB total is fine.
32GB will become the bare minimum soon though; as future Motherboards will most likely offer the newer CAMM2 type of RAM.
with 3 lane memory support and 6 ramsockets, so you did 8x8Gb ddr3??
that is a system from 2011.. while it WAS thousands of euro back than.. and the best there than it is old like 14 years old.. as pc generations are on averey 1.5-2 years apart and you replace your pc normally every 2 generations.. you see how thats basicly an antique..
that cpu will give even the 4060 and 3060 a bottleneck of about 20% (meaning only 80% gets used)
ofcourse thats without overclock so with an overclock it likely can support that card..
realisticly though
it could likely support an 3050... or an 1660ti/1660S at best.. which still can give you 90fps in 1080p. which is playable for some..
Modern Motherboards support 1x 48GB in each slot. Yes they make 48GB DDR5
How is this news to folks? Please try to keep up.
I suspect the OP is doing 2x 16GB + 2x 8GB; which is 48GB
But I would not do that since many Motherboards don't do well with all 4 slots populated at the same time. Better to do 2x 16GB or if the board supports it; do 2x 32GB or 2x 48GB
ah right... 24gb and 48gb dims.. I knew... just not naturually was the first thing I though.. I still find thouse odd and have not buiild with them... lets say the old binary numbers just are to hardwared I ran DREAM the 2 4 8 16 etc.. numbers range..
was thinking he was doing something funky like 2x16 and 2x8 which would be stupid.
or indeed he might have picked up an x58 system at the cheap like 10-50 euro stick a newer gpu in it for also like 50.. and call it a day.
as for slots
I have ran 8x16GB for years now.. it works fine... on a 4 lane motherboard
it is bullocks 4 slots utilised is bad...
what is however true is that you only have 2 lanes.. on mainsteam motherboards if all 4 ramslots are full that means all data will have to travel trough 2 dims which gives some delay
but very minor.
yes 2 larger sticks do tend to run faster than 4 smaller ones.. and generally the price difference between 2 sticks of 32gb and 4 of 16 is minimal... so not really an issue.
main reason I generally advise people to use 2 slots when building a system is so they keep the option open to double their ram in the future without having to toss what they already got.
as long as matching dimms are in the matching slots, it will be dual channel
but be sure to use the xmp profile for the dimm with higher timings