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If its an 8GB stick that'll be fine
But all in all, Dual Channel is better, but theres no harm in just using one.
Aside from (slightly) less performance.
Read more at http://www.hardwaresecrets.com/does-dual-channel-memory-make-difference-in-gaming-performance/7/#4Y4VCXM9D4VTqyjG.99
TL;DR: barely noticeable when it comes to gaming. Very noticeable when it comes to memory intensive tasks like video editing.
At the end of the day, if you have a motherboard with 4 slots, just spend the extra 5 bucks and get 2x4GB. If you have 2 slots and you really, really, really can't afford to go to 2x8GB now, you could go for the single stick.
As for saving space for future upgrades it's only really relevant on mini-ITX motherboards (two slots) and laptops (two slots), micro-ATX and ATX you have at-least four slots normally (not with H110 for instance, with B150 you should have) and hence even if don't want to get the higher amount of RAM right now you'd still have two slots available later.