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if its hot, clean its vents and coolers
No idea as League of Legends doesn't do that for me while loading client or game itself across nearly half a dozen PCs, nor is it that demanding.
Quick check would be limiting your FPS to your refresh rate in Nvidia or and control panels to check if that solves the issue
Get a kitchen roll tube, or make one out of an A4 sheet of paper. Listen for where the sound comes from inside the PC with it, it should help finding it easier.
Make sure to monitor your temps to make they're <70c.
And an FPS limiter (like RTSS) could be used to limit FPS to see if it stops this sound, in the event that it's coil whine, this would be the only fix short of desoldering the indicators.