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To keep dual channel and all the RAM working under that.
Just ensure the new RAM has the same specs as the current.
Otherwise they will not mesh well together.
While this will be maxing out your 4 DIMMs, 24GB is plenty
The motherboard will find the lowest common denominator between the sticks (lowest speed, loosest timings). But even that will hardly be noticeable.
Still doesn't make sense to do it the way the OP was suggesting.
Now if this was a new build and you were perhaps getting a better deal on 1x 16GB; then go for it. But 2x 4GB + 1x 16GB; yea makes no sense to do it that way.
You want all RAM to match, 100%, and apply XMP to lock in correct settings.
You never use "Auto"; that is merely to help ensure the system boots when trying "defaults"
For twenty years I've never seen more than an minor performance difference in the same generation of memory matter anywhere but at the extreme ends, or benchmarks. Neither are relevant in this case. Memory speeds/timings just aren't a bottleneck in real world consumer/gaming applications. Size of it is. Set it if you want, it won't get you a single frame per second more.
If they don't match; that leads to all sorts of random issues. Do not do it.
1x16GB vs 2x8GB costs virtually the same $; so why go 1x16GB
Overall, just match all RAM specs and enable XMP you'll be fine.
@OP: check the voltage and the XMP profiles. If the voltage is the same and at least one of the XMP profiles is the same, it's perfectly fine.