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One potential problem is it could break your saves depending on how its coded and what the DLC is, i.e. if you play and save with the DLC active, then untick it and reload the save the game might expect you to have DLC items you don't which causes a conflict.
The reality is you'll only really know what the impact is by trying yourself when it becomes available, Which is why you haven't found an answer because the answer is it depends.