What should I focus on first?

[Gønzö]

The main quest line then side quests?

Or just meander about as I will and eventually get to everything.

[Bubba & Friends]

I'm 75 hours in, 98% complete, I didn't focus on anything! I did a mixture of side quests with good rewards and i went back on the main quest once I completed the good reward side quests.

[Gønzö]

Originally posted by It's Just Boris:

I'm 75 hours in, 98% complete, I didn't focus on anything! I did a mixture of side quests with good rewards and i went back on the main quest once I completed the good reward side quests.

Nice. Thats good to hear, I usually do that myself so I’ll probably keep doing that!

[Pocket Dog]

You're going to have to do main quests to unlock things, like potion making, learning certain spells, getting your own wand, getting access to talents, earning your broom, etc., yet you can also acquire some good stuff from side content as well. It's really to your benefit to do both, not focus on one over the other.

[Lonetac]

do the main quests as you need to unlock everything or you will be doing a lot of back tracking. Once you unlock astronomy you have nearly everything unlocked i believe.

[Gønzö]

Originally posted by Lonetac:

do the main quests as you need to unlock everything or you will be doing a lot of back tracking. Once you unlock astronomy you have nearly everything unlocked i believe.

Interesting. Thanks!

[lnomsim]

Main quests will give you spells and gameplay elements that will help you progress in fights, sidequests and side activities.