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God of war is a good choice, it'll buff your clockwork sawblades. If you have a means of teleporting and a big stack of thrown weapons Dredmor shouldn't be too much of a problem. If you're worried about incoming spell damage, now is the time to start chewing on the grunge ears you've probably had piling up.
Another easily overlooked thing: Encrusting. While what exactly you can do depends on your crafting stats, there are plenty of useful stat boosts to be had that way. If you're worried about instability, only add one encrust per item. The first one is always safe no matter what.
Dredmor's scariest skill is probably Fulminaric bolt, so boosting your voltaic and blasting resistances should help. He's also vulnerable to silence if you have any sonic wands kicking about.
So I've got about 8 floors of dual-charge anvils waiting to buff my end-game eq, and 7 floors of one-charge anvils. Should I just go buff everything up, or is it risky to to use anvils on super-high level eq because I can't replace it if they get debuffed hard?
Consider buffing your sight range, using say a potion of clear vision. If you can see Dredmor but he can't see you that's another couple of turns of throwing stuff without getting a fulminaric bolt to the face in retaliation.
Like I said at the start though, Dredmor really isn't that hard. With a teleport skill, a high melee damage stat and a good stack of clockwork sawblades you'll shred him, no problem.
I come from Dota 2. Let me tell you; the difference in community is literally night and day. :P