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1. Rogue Scientist
2. Alchemy
3. Tinker
4. Perception
5. Promethean
6. Ley Walker or Blood Mage, as you prefer, but NOT BOTH (this really is not a build that requires both). Nowadays, I tend to favor Ley Walker, but Blood MAge has its virtues as well.
7. Mathemagics or Burglary, as you prefer (they have overlapping virtues, so I probably would not take both). I lean towards Burglary, myself, but you sound like you want a more mage-heavy build, so go with Mathemagics. The advantage of Mathemagics is that it has great single-target attacks, and it is a mage skill, which has a little bit extra synergy with other mage skills.
My prefered build out of this would be:
RS, Alchemy, Tinker, Perception, Promethean, Ley Walker, Burglary.
I think ill try RS, Alchemy, Tinker, Perception, Promethean, Ley Walker and Math first
I hope with Tinker and Perception I'll have enough to manage traps. this'll be new territory. I almost always include burglary.
I'm still undecided between Blood Mage and Ley Walker, but I'm choosing the latter this time. Mostly because i haven't leveled it past Tap and I wanna see how well it handles later on. Also, Tap has saved so many of my mages in the past.
I'll let yah know how it goes
As for leywalker, don't bother taking the final skill. It's inferior to Mathemagic's Xeuclid's transformation in pretty much every way.
So far I bumped Ley Walker once.
1 point into RS.
Next ones went to rune and and pet.
Pushed alchemy up to brimstone.
I went straight to cannister after that.
1. Roguescientist (Core theme of build mentioned)
2. leylines (mana regen/teleport)
3. Lawmagic (instant refresh of those OP skills for mana cost/silence/reflect 50% skill)
4. Perception (loot/ingots)
5. Tinkering (traps and skill enhancer)
6. Alchemy (amazing potions and skill enhancer)
7. Mathmagic or promethian (imho crossbow would be a better choice)
promethian is good to but only for that fire wyvern summon. Spells suck after floors 7+ cept for the flame pillars you can spam all over the place. Take note im only considering this by mana efficiency. You can still clear all levels of dredmor with this skill but it takes far too much mana. Roguescientist skills can do this for free and only need 1 or 2 hits.
Why is crossbow a better choice? With the high alchemy/tinkering you can craft bolts of mass destruction and really highlevel base bolts. Alchemy gives access to the elemental bolts and encrusting for lifesteal or pushaway on hit skills. Crafting a bunch of brimstone potions makes for effective room clears levels 1-7 and softeners for 7+ ontop of your clear abilities.
Perception gives you endless amounts of iron and steel if you use "Craft 'n smelt" mod. Even with out that mod it still drops iron/steel/random ingot very often as well as other good items the real bonus is that +dodge and +reduced enemy dodge stats sight vision makes you more aware/ready and you can throw grenades/shoot at a silly distance because you see FAR. Crossbow can 1 shot elites that your base skills can't, so elites you need dead rightaway can be dealt with safely.
(Of course this is assuming you have bolt thrower or railgun bow and the strongest leveled steel bolts with some encrusts or kronged elemental buffs).
Leylines last skill has teleport so you don't need mathmagic.
Rogue skills with instant cooldown refresher replaces the need for constant AoE dps promethian provides because rogue skills already does that and has even stronger single target dps too.
When playing as any rogue/mage i suggest having a few concussion bombs to knock things away if you don't have a skill to do so already.
Mathmagic's only useful skill's imho is teleport, Zenzizenzizenzic and recursive curse. It doesn't scale very well into the end because of the common damage types it deals. Even with high spell power the spells really suck. Except for Recursive curse, that spell just amazing.
Here's the absolute kick to the chin though. If you come across galactic pan garblaster or w.e its called. That booze gives you Zenzizenzizenzic with out taking mathmagic skill. That buff alone and recursive curse is the only reason to use it. Burglary and artful dodger is better for movement altogether imho. Curse of golden ratio is only useful on difficulties that don't charge 1-70k gold for a crap item or "useful" item. With burglary you can just steal items with out getting caught and certain stores you can exploit stealing with out getting caught too. Of course if your level 15+ you can just kill everything/everyone and take what ever the hell you want lolz.
Leyline is probably better for a pure wizard build, since you can get the very useful 1 MP per turn regen with it, not to mention the wonderfulness of thaumaturgic tap.
Blood magic is probably better for a melee magic user, say people who go with viking magic, vampire or warlock. Since you're not using your MP regen stat to get the MP, you can afford to wear heavy armours, and you're not taking turns to cast tap in the middle of a fight.