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True, but you also are exposed to a lot more plasmids/vigors and use them way more. It's not like one cigarrette, it's like an entire case. That has to have some effect. The thing i remember from B1 and B2, aside from the deformities caused by plasmid use is the going insane. Both Jack and Booker have zero sanity issues, not even a little bit? I call bologna.
Even smoking a box of cigarettes in one day won't have much of an effect on me.
However many plasmids they have and use it probably takes prolonged usage for you to lose your sanity because of them. If Jack (and Booker) stops using his plasmids after the events of B1/BI then I don't see why they'd necessarily see any ill effects.
Not true. They just haven't been in Columbia as long. Look at Slate. He has crystals growing out of his head, and he certainly isn't completely sane.
I would argue that Slate is completely sane. He and his men want to die honorably at the hands of a real man, rather than at the hands of Comstock's goons.
In BaS most people seem sane enough, even though Plasmids had been around for a time, so I suppose it was only those who really binged on the stuff that became splicers.
Edit: Jack does get the hallucinatory side effect with the ghosts, though.
^ This xD