How to decide, which enemies to kill

[easylife]

My recommendation for the decision, which enemies to kill:

- Lickers: No need to kill, walk slowly pass them, (Except Hallway at STARS Office A-Route)
- Dogs: Run, run, run. But not always straight
- G-Adults: Run, avoid with timing (Wake up lurking ones with a Hand gun Shot, then evade the grabbing left hand with a backstep)
- Ivy Zombies: No need to kill. Either avoid them, run pass them or stun with one Shotgun or Magnum shot, then run pass them.
- Tyrant while patrolling: Run or wait in a safe room. No need to waste a single round of ammo. Don’t alert him with the sound of gunfire

For Zombies:
- Zombies in Rooms and Hallways, where you only run through one time: run, evade or stun with a gunshot and run pass them
- Zombies in Locations, where you need to pass several times: It’s better to kill them, to avoid getting ambushed the next time
- Zombies in Hallways, where you need to run when Mr.X is patrolling. Kill the zombies before Mr.X spawns.

In general, killing enemies takes time which you don’t want to waste, when making a S(+)- Rank playthrough. It is also often a waste of ammo. If you don’t know how to avoid/evade Enemies, you can learn a lot from speed runner’s YouTube Videos.

[easylife]

Tipps for Mr.X / Tyrant first encounter:

A-Route: While he lifts the helicopter wreck, run back and go down the stairs. When he does not see you, he will go back patrolling

B-Route: Before entering the STARS Office proceed a bit and spawn Mr.X. Then loot the STARS office. In the meantime, he will walk towards the shower room, as Mr.X cannot open closed doors. Unlock the door towards the library and proceed. (Be aware that he can sometimes be in the linen room)

[zmanbuilder]

If it moves, it dies. Unless it is outside.

[SunnyC]

kill everything with a knife

[DessIntress]

Enemies lying on routes that you obviously have to travel multiple times are killed. The rest is optional or situation-dependent. The principle works in every RE. It's usually very clear where you have to travel multiple times: large halls, long corridors, stairwells, rooms in which you cannot currently use something. The usual suspects. What you leave alive in such places can become a problem later.