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Sometimes you can have both for example the bride has a good stress attack and great physical attacks.
I dont know/remember but I vaguely recall there may have been a body part advantage for stressing enemies to death instead of pure damage.
Artifact available which increases Iratus XP for each enemy dying from a heart attack. No difference in parts gained.
Generally, the only enemies I actually prefer to kill with stress are the Wardens (they have good armor values and ignore all standards debuffs, but they're easily driven insane) and Failed Experiments (they self-destruct for immense damage if you lower their massive HP pool below 25%, but you can bypass this with a stress kill).
I've heard that most of the bosses are also easier to kill via heart attack, but I haven't tested this out.
Lastly, it's hard to set up a good stress team that actually has a strong frontline for survival purposes; most of the good tanks are physically oriented (Bone Golem, Ghoul, etc.) while even the mediocre tanks only get their dedicated stress skills as ability upgrades after some leveling (Zombie, Black Widow, etc.).
Some bosses may be easier with stress but the Act 2 Dwarf is absolute hell with a stress team, last time I made one I had to create a physical team just for him and I have doubts about the Fire Mage as well since her always-respawning minions are immune to stress iirc so you're gonna eat a ton of self-destructs.
A strong elite enemy triggering a powerful Inspiration instead of an Insanity can completely turn a fight sideways. Feels really crappy when this happens.
There's also two insanities that can be very dangerous to you (the one that allows the enemy to act twice in one turn and the one that buffs the enemy damage).
Played up to Good Always wins and stress teams worked fine even on the final boss, it just depends on what you wanna do imo. If you can't stand possibly waiting another round for heart attacks to occur then it may not be for you, but I've never had much issue with it.