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Stellaris
Avorian
eve online, ugh
Homeworld
Reassembly
Spacae Engineers
Space Pirates and Zombies
Starpoint Gemini
See if any of those are anything close to what you are asking for.
I think Consuela got most of the games that could be relevant, personally I think Avorion might be the best fit but there really is no good game like this that also comes with a robust "CIV" experience as well, at least none that I have heard of.
Even though it has close to 0 in common with what you were asking for I still have to recommend Crusader Kings 3 for anyone wanting some fun multiplayer with friends simply because you can really mess with people in it without completely ruining their game and you can get some hilarious scenarios happening.
Avorion is my all time favorite though with hundreds of hours (since early alpha)...
Starcom Nexus - has an story n more rpg to it.
Stardeus - think Rimworld, but in space.
Star Control Origins - very colorful story driven rpg space game, bout saving humanity.