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Rebirth, Crossing Souls and Mediterranean Diet are all missable (and Bronze Medal + Requiem Aeternam coz of conditions ofc) so you might want to check what to do exactly ;-)
You can also do all collecting relatd achievs after game is finished so I would say 2 runs, where in second run you can do bosses without Flasks as you are already somewhat familiar with them and as long as you dong chug that Flask you cant mess that up (I did A ending and Rebirth in my first)
Then make separate save and just run for Bronze Medal
If you want to go for 100% :)
Just a slight clarification to the highlighted answer: Every item in the game can be gotten later if the conditions for getting it early are not met.
The only things that are not available in one playthrough are certain challenge based achievements; and the "bad" ending becomes unavailable if you complete the quest for the "good" ending.
Even both endings can be gotten in one playthrough by beating the game without doing the Confessor Statue quest, then reloading your save and doing the quest before beating the last boss again.
Does that mean I'm gonna be able to collect items later which i missed cause i screwed Gemino quest?I can not access the cave which Gemino is supposed to open which contains rosary bead.
Furthermore I can't turn on last healing item to the guy in Albero cause i killed some of the later bosses early.How can i get his rosary knot which is he supposed to give me?
You can access "Gemino cave" by dropping in the near spot with equipped relic that will let you survive all falls (Linen of Golden Thread) thus it is not even mentioned here
Rosary Knot from Tirso is not mentioned here coz as long as you wont kill ALL bosses 'till you turn in all herbs you wont lock it up.
But tbh it should be mentioned, as that achiev for that quest is still missable (you need to turn every herb asap as you get it)