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Though there are two, maybe three points [first one is in Neptune's Bounty] where there are glitchy extra little sisters and those do not respawn if they escape. it doesn't matter if you miss those, though, they count towards your total and do give you Adam but they are glitched extras so even without them you should be fine.
now she's really dead
She's gone
someone hjelp
Just wander around the area and you will find another Big Daddy/Little Sister.
I do find that, early on in the game, killing a Big Daddy uses a lot of scarce ammo (grenades, armor-piercing etc) and if you don't get the Little Sister, it can feel like a big waste.