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disk file system corrupt. run check the drive for system errors.
disk full. make sure there is space.
permission problem. run steam as admin.
antivirus blocking the game. check your antivirus logs.
mods are causing problems.
I just had this issue now as well and found another reason what causes it (Windows 10).
It's the ransomware protection which needs to be disabled in order to resolve the issue.
It can be disabled by going to Start -> Settings -> Updates and Security -> Windows Security -> Virus protection -> Ransomware protection -> There you can turn it off.
Once it's disabled you should be able to save again. No need to disable your Antivirus (at least from my experience).
Is there another way to fix this without turning off ransomware protection?