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It's not unusual to have negative health during the mid-game. It can be prevented, but usually it's still more efficient to expand and just bear the negative health until you have the production base, buildings, or virtues, to fix it.
Anyway, when it comes to dealing with health, until you have a good number of cities it's pretty much pointless to even bother with it. The penalties are very small until you have a lot of cities and population for those penalties to affect, at which point you're either much more capable of dealing with health (mostly from Eudaimonia or Magnasanti) or you've basically already won anyway.