What to unlock?

[Beloved Pucci]

There are so many items and i read a lot are bad, so wich ones i unlock/ what stats i focus? i dont want to bloat my save with subpar items :(

[TreasureCat]

I'm also curious about this, having only done a handful of runs.

I mostly favor stagger bonuses. Peacekeeper Implant was a no brainer for me and has been useful basically everytime it turns up. Retribution Gauntlet is also fantastic. Put both of those on an Archon and enjoy using your near instant AOE Discharge for 50+ second staggers every turn.

[Aggressor]

It really depends on your party composition, but I can give you what I choose:
For Aegis: Ultimatum Implant. (I unlock this one) This implant allows the Aegis to redirect attacks to her and absorb damage that would otherwise hit weaker DPS characters.
Maelstrom.- This is also nice for the Aegis, adding stagger to her shield throw.
Collossus- Good for defense for just about any character.
Exalter- This is great when you get the Empath or Archon, it will add shields to their regeneration abilities.
For Spectre: Requiem Rifle + Galvanizer implant + Defiler Sword. When you have these at high levels, they turn the Spectre into a one-shot boss curb stomper. I have had almost 2000 points of damage in one hit with these items leveled on the Spectre.
For Enforcer: Biorifle - This gun works well for him, and allows him to stand on the front line because you don't have to worry about his health declining.

These choices are pretty good, and for my starting 3 of Aegis , Enforcer and Spectre will work out well. But when it comes to items you have to make the best of what you get, save coins to choose better gear , and sell gear when it means you can upgrade.

[Samseng Yik]

I unlock everything, if something that seems then I downgrade the items.
I never afraid of "bad item" appear like in Dead Cell I also unlock everything for the sake of "random fun" and adapt to whatever happen

[Krutsi]

Generally speaking, armor damage, armor piercing, shield piercing and shield damage are weak effects and you should ignore items with these bonuses.

You need to buy atleast one item of every price tier to unlock the next one, so for starters the absolute best in their cost tier items which you probably should prioritize buying are:

Colossus (15, device)
Retribution (30, fist), Abomination (30, pistol), Defiler (30, sword)
Peacekeeper (45, implant), Exalter (45, device)
Willbreaker (60, implant), Biorifle (60, rifle)
Desecrator (75, rifle)
Boneslicer (90, sword), Nadir (90, device)
Nanogauntlets (105, fist) *Not that strong but need to pick something
Debilitator (120, rifle)

Apart from these, other items that are generally useful but for me lower priority than the above:

Seether (90, pistol)
Galvanizer(90, implant)
Requiem (90, rifle)
Conquest (120, pistol)
Maelstrom (120, fist)
Zenith (120, sword)